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Use of the Triggering Receptor Expressed on Myeloid Cells-1 (TREM-1) in the Diagnosis of Pleural Effusion

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ClinicalTrials.gov Identifier: NCT00166894
Recruitment Status : Unknown
Verified May 2005 by National Taiwan University Hospital.
Recruitment status was:  Recruiting
First Posted : September 14, 2005
Last Update Posted : November 24, 2005
Sponsor:
Information provided by:
National Taiwan University Hospital

Study Description
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Brief Summary:
The aim of this trial is to evaluate the level of TREM-1 in different kinds of pleural effusion.

Condition or disease
Pleural Effusion

Detailed Description:
The triggering receptor expressed on myeloid cells-1 (TREM-1) is a member of the immunoglobulin superfamily, and its expression is upregulated on phagocytic cells in the presence of bacteria or fungi. Several experiments by Bouchon and colleagues showed that TREM-1 mediates the acute inflammatory response to microbial products. Human tissues infected with bacteria are infiltrated with neutrophils and macrophages that express high levels of TREM-1. Conversely, TREM-1 is only weakly expressed in samples from patients with noninfectious inflammatory disorders. In addition, TREM-1 is shed from the membrane of activated phagocytes and can be found in a soluble form in body fluids. The presence of a soluble form of TREM-1 in samples of bronchoalveolar lavage fluid from mechanically ventilated patients has been shown to be a good indicator of infectious pneumonia.

Study Design
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Study Type : Observational
Enrollment : 100 participants
Allocation: Random Sample
Observational Model: Natural History
Time Perspective: Cross-Sectional
Time Perspective: Prospective
Official Title: Evaluation of the Triggering Receptor Expressed on Myeloid Cells-1 (TREM-1) as a Diagnostic Tool for Patients With Pleural Effusion
Study Start Date : May 2005
Groups and Cohorts
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Outcome Measures
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Eligibility Criteria
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Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Clinical diagnosis of pleural effusion
  • Pleural effusion proved by chest sonography

Exclusion Criteria:

  • Conditions for which thoracentesis are contraindicated
  • Pregnancy
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00166894


Contacts
Contact: Pan-Chyr Yang, MD, PhD 886-2-2356-2867 pcyang@ha.mc.ntu.edu.tw

Locations
Taiwan
National Taiwan University Hospital Recruiting
Taipei, Taiwan
Contact: Pan-Chyr Yang, MD, PhD    886-2-2356-2867    pcyang@ha.mc.ntu.edu.tw   
Principal Investigator: Pan-Chyr Yang, MD, PhD         
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
Principal Investigator: Pan-Chyr Yang, MD, PhD Department of International Medicine, National Taiwan University Hospital
More Information
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ClinicalTrials.gov Identifier: NCT00166894     History of Changes
Other Study ID Numbers: 9461700516
First Posted: September 14, 2005    Key Record Dates
Last Update Posted: November 24, 2005
Last Verified: May 2005

Keywords provided by National Taiwan University Hospital:
pleural effusion
TREM-1

Additional relevant MeSH terms:
Pleural Effusion
Pleural Diseases
Respiratory Tract Diseases