Value of FLT-PET Before and During Radiotherapy in Head and Neck Tumors
Tumor cell proliferation and repopulation contribute to resistance to radiotherapy in head and neck cancer. Up to now, this characteristic is mostly assessed using biopsies acquired during inspection under general anaesthesia before treatment.
18F-FLT-PET (positron emission tomography) is a non-invasive imaging method showing areas of active proliferation. The aim of this study is to assess the value of the functional information gained by 18F-FLT-PET for radiotherapy planning and early tumor response assessment.
Prior to radiotherapy, a planning CT-scan and a 18F-FLT-PET scan are acquired. After approximately two weeks of radiotherapy a further PET scan is obtained.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Value of FLT-PET Before and During Radiotherapy in Head and Neck Tumors|
- Correlation of 18F-FLT-PET-signal changes before and during therapy with treatment outcome (clinical response and local tumor control) [ Time Frame: 1 year ] [ Designated as safety issue: No ]
- Evaluation of the value of the functional information gained by 18F-FLT-PET regarding the definition of the planning target volume (PTV) for radiotherapy. [ Time Frame: 2 months ] [ Designated as safety issue: No ]
- Measurement of 18F-FLT-PET-signal changes during radiotherapy or radiochemotherapy. [ Time Frame: 2 months ] [ Designated as safety issue: No ]
|Study Start Date:||July 2005|
|Study Completion Date:||December 2010|
|Primary Completion Date:||December 2008 (Final data collection date for primary outcome measure)|
Please refer to this study by its ClinicalTrials.gov identifier: NCT00163176
|Radboud University Nijmegen, Department of Radiotherapy|
|Nijmegen, Gelderland, Netherlands, 6500 HB|
|Principal Investigator:||Johannes HA Kaanders, PhD||Radboud University|