Relation Between Maternal Iodine Status and Prenatal Foetal Thyroid Dimension
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|ClinicalTrials.gov Identifier: NCT00162539|
Recruitment Status : Completed
First Posted : September 13, 2005
Last Update Posted : July 26, 2012
|Condition or disease||Intervention/treatment||Phase|
|Deficiency Disease||Other: echography||Not Applicable|
Iodine is an essential element in thyroid homeostasis, particularly in pregnant woman and her fetus. Various studies have clearly shown that antenatal thyroid disorders at both the mother and the fetus could cause in extreme situations of neurological consequences.
At a broader scale, subtle alterations of thyroid hormone balance has been implicated in developmental delays and deviations of the IQ bell curve in newborn infants of mothers with elevated TSH.
The clinical implications of these basic data and public health are yet to confirm.
It has been clearly established that there is a moderate iodine deficiency in France with a decreasing gradient from west to east. In the Ile de France, there is a moderate iodine deficiency, this has led some teams to propose a systematic supplementation of all women in iodine.
One way to target women who really need supplements systematic determination of urinary iodine tongue; this assay is reliable but is difficult to implement in an ad hoc practice at the individual level.
Our team has expertise in the field of fetal thyroid, particularly in its sonographic and reference curves of the perimeter and diameter of the thyroid are now clearly established reliably.
Knowing that iodine deficiency is causing a decline in maternal urine iodine with a phenomenon goitrigénèse and biological hypothyroidism and that some studies have shown that neonatal thyroid volumes were higher in iodine deficient mothers . We postulate that the measurement of fetal thyroid by our criteria can be correlated with maternal urinary iodine.
If this were the case, we will have a simple test to identify iodine supplementation in pregnant women.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||130 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Relation Between Maternal Iodine Status and Prenatal Foetal Thyroid Dimension|
|Study Start Date :||October 2005|
|Actual Primary Completion Date :||June 2006|
|Actual Study Completion Date :||June 2006|
- establish a relationship between maternal urinary iodine and thyroid measurements of fetal [ Time Frame: final time frame at the end of the study ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00162539
|Paris, France, 92110|
|Principal Investigator:||Dominique LUTON||Assistance Publique - Hôpitaux de Paris|