Genetics and Psychopathology in the 22q11 Deletion Syndrome

The recruitment status of this study is unknown because the information has not been verified recently.
Verified October 2004 by UMC Utrecht.
Recruitment status was  Recruiting
Netherlands Brain Foundation
Children's Hospital of Philadelphia
Information provided by:
UMC Utrecht Identifier:
First received: September 8, 2005
Last updated: October 12, 2006
Last verified: October 2004

The purposes of this study are to:

  1. study the nature and longitudinal course of psychiatric symptoms in children with the 22q11.2 deletion syndrome and
  2. identify genes that contribute to the occurrence of these symptoms.

Chromosome 22q11.2 Deletion Syndrome

Study Type: Observational
Study Design: Observational Model: Defined Population
Time Perspective: Longitudinal
Official Title: Genetics and Psychopathology in the 22q11 Deletion Syndrome

Resource links provided by NLM:

Further study details as provided by UMC Utrecht:

Estimated Enrollment: 175
Study Start Date: October 2002
Estimated Study Completion Date: October 2012
  Show Detailed Description


Ages Eligible for Study:   8 Years to 20 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • 22q11.2 deletion confirmed with fluorescence in-situ hybridization (FISH)

Exclusion Criteria:

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00161109

Contact: Jacob AS Vorstman, M.D. 215 590 3863

United States, Pennsylvania
Children's Hospital of Philadelphia, Dpt of Genetics and Dpt of Child and Adolescent Psychiatry Recruiting
Philadelphia, Pennsylvania, United States, 19104
Contact: Jacob AS Vorstman, M.D.    215-590-2862   
UMC Utrecht, Dpt of Child and Adolescent Psychiatry Recruiting
Utrecht, Netherlands, 3508 GA
Contact: Herman van Engeland, M.D., Ph.D.    +31 30 2506362   
Sponsors and Collaborators
UMC Utrecht
Netherlands Brain Foundation
Children's Hospital of Philadelphia
Study Director: René S. Kahn, M.D., Ph.D. UMC Utrecht, The Netherlands
  More Information

Additional Information: Identifier: NCT00161109     History of Changes
Other Study ID Numbers: P03.0377C 
Study First Received: September 8, 2005
Last Updated: October 12, 2006
Health Authority: Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)

Keywords provided by UMC Utrecht:
22q11.2 deletion syndrome
Deletion size
Candidate genes
Psychiatric symptoms
Neuropsychological impairments
Psychophysiological performance

Additional relevant MeSH terms:
Craniofacial Abnormalities
22q11 Deletion Syndrome
DiGeorge Syndrome
Abnormalities, Multiple
Cardiovascular Abnormalities
Cardiovascular Diseases
Chromosome Disorders
Congenital Abnormalities
Endocrine System Diseases
Genetic Diseases, Inborn
Heart Defects, Congenital
Heart Diseases
Lymphatic Abnormalities
Lymphatic Diseases
Musculoskeletal Abnormalities
Musculoskeletal Diseases
Parathyroid Diseases
Pathologic Processes processed this record on May 26, 2016