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The Use of Repetitive Magnetic Stimulation for Strength Training of the Quadriceps Muscle

This study has been completed.
Magstim Company, Whitland, Wales
Information provided by:
Imperial College London Identifier:
First received: September 9, 2005
Last updated: February 16, 2016
Last verified: August 2008
We intend to use repetitive magnetic stimulation to the quadriceps muscle to try to improve strength and improve the metabolic function of the muscle.

Condition Intervention
Chronic Obstructive Pulmonary Disease Device: Repetitive magnetic stimulation to the quadriceps

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: The Use of Repetitive Magnetic Stimulation for Strength Training of the Quadriceps Muscle in Patients With Chronic Obstructive Pulmonary Disease

Further study details as provided by Imperial College London:

Primary Outcome Measures:
  • Quadriceps Twitch force

Secondary Outcome Measures:
  • Quadriceps maximal voluntary contraction, Oxidative enzyme profile, fibre type distribution and capillarity of the muscle, quality of life questionnaires

Estimated Enrollment: 20
Study Start Date: January 2005
Study Completion Date: February 2006
Primary Completion Date: February 2006 (Final data collection date for primary outcome measure)
Detailed Description:

Quadriceps strength is reduced in COPD. Increasing quadriceps strength is one of the goals of pulmonary rehabilitation yet some patients with severe COPD are unable to exercise with sufficient intensity, due to breathlessness, to achieve a true training benefit.

Transcutaneous electrical stimulation of the femoral nerve has been shown to improve quadriceps muscle strength, muscle mass, and performance in patients with severe COPD. Magnetic stimulation may be preferred because it offers the opportunity to train the whole muscle and because it is painless. In this pilot study we are investigating whether repetitive magnetic stimulation camn increase the strength of the quadriceps muscle and whether it confers any change in structure or metabolism of the muscle itself.


Ages Eligible for Study:   40 Years to 85 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

Chronic Obstructive Pulmonary Disease

Exclusion Criteria:

Aspirin therapy Cardiac Pacemaker

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Please refer to this study by its identifier: NCT00159367

United Kingdom
Royal Brompton Hospital
London, United Kingdom, Sw3 6NP
Sponsors and Collaborators
Imperial College London
Magstim Company, Whitland, Wales
Principal Investigator: Michael I Polkey, PhD Imperial College London
  More Information

Responsible Party: Professor Michael I Polkey, Royal brompton Hospital/Imperial College Identifier: NCT00159367     History of Changes
Other Study ID Numbers: RR1
EU QLRT-2001-2285
Study First Received: September 9, 2005
Last Updated: February 16, 2016

Keywords provided by Imperial College London:
Neuromuscular electrical stimulation

Additional relevant MeSH terms:
Lung Diseases
Lung Diseases, Obstructive
Pulmonary Disease, Chronic Obstructive
Respiratory Tract Diseases processed this record on September 25, 2017