ATP/AMP Challenge in Healthy Non-smokers, Smokers, Patients With Asthma, and Patients With Chronic Obstructive Pulmonary Disease (COPD)
In this randomised, cross-over, controlled study, a total of 84 subjects will be included: 12 healthy non-smoking volunteers; 12 current smokers; 30 patients with mild steroid-naïve asthma; and 30 patients with mild-moderate COPD.
Each subject will have 1 screening visit (if necessary) and 2 study visits. At visits 2 and 3 the effects of adenosine 5`-triphosphate (ATP) or adenosine 5`-monophosphate (AMP) challenge, given in a random order, will be tested.
Procedure: Inhalation Challenge with ATP
Procedure: Inhalation Challenge with AMP
|Study Design:||Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Open Label
|Official Title:||Adenosine 5`-Triphosphate (ATP) Challenge in Healthy Non-smokers, Current Smokers and Patients With Mild Asthma and Chronic Obstructive Pulmonary Disease (COPD)|
Please refer to this study by its ClinicalTrials.gov identifier: NCT00159315
|Section of Airway Disease, Asthma Lab, Imperial College London, Royal Brompton Hospital|
|London, United Kingdom, SW3 6LY|
|Principal Investigator:||Sergei A Kharitonov, MD, PhD||Imperial College London|