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Genetics of Alpha Thalassemia in Israeli Ethnic Groups

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Deborah Rund, Hadassah Medical Organization
ClinicalTrials.gov Identifier:
NCT00159029
First received: September 9, 2005
Last updated: August 9, 2017
Last verified: August 2017
  Purpose

Alpha thalassemia causes mild anemia and is found in many ethnic groups. Usually it is found in regions where malaria is endemic. We have found that alpha thalassemia is common in Ashkenazim, whose countries of origin are in temperate climates.

We are analyzing the alpha globin genes of individuals of many ethnic groups and will compare to try to define the origin of thalassemia in these individuals of European extraction.


Condition
Alpha Thalassemia

Study Type: Observational
Study Design: Observational Model: Other
Time Perspective: Other
Official Title: Haplotype Analysis of Alpha Globin Genes in Israeli Ethnic Groups

Resource links provided by NLM:


Further study details as provided by Deborah Rund, Hadassah Medical Organization:

Biospecimen Retention:   Samples With DNA
DNA isolated from peripheral blood.

Enrollment: 100
Actual Study Start Date: April 1, 2004
Study Completion Date: July 1, 2017
Primary Completion Date: July 1, 2017 (Final data collection date for primary outcome measure)
Detailed Description:

Alpha thalassemia causes mild anemia and is found in many ethnic groups. Usually it is found in regions where malaria is endemic. We have found that alpha thalassemia is common in Ashkenazim, whose countries of origin are in temperate climates.

We are analyzing the alpha globin polymorphisms to determine the haplotypes of individuals of many ethnic groups and will compare to try to define the origin of thalassemia in these individuals of European extraction.

  Eligibility

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients who come to Hadassah Hospital for anemia with microcytosis who are found to have alpha thalassemia.
Criteria

Inclusion Criteria:

  • diagnosis of deletional alpha thalassemia

Exclusion Criteria:

  • under age 18
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00159029

Locations
Israel
Hadassah Medical Organization
Jerusalem, Israel
Sponsors and Collaborators
Deborah Rund
Investigators
Principal Investigator: Deborah Rund, MD Hadassah Medical Organization
  More Information

Publications:
Responsible Party: Deborah Rund, Senior Hematologist, Hadassah Medical Organization
ClinicalTrials.gov Identifier: NCT00159029     History of Changes
Other Study ID Numbers: 152910-HMO-CTIL
Study First Received: September 9, 2005
Last Updated: August 9, 2017

Additional relevant MeSH terms:
Thalassemia
alpha-Thalassemia
Anemia, Hemolytic, Congenital
Anemia, Hemolytic
Anemia
Hematologic Diseases
Hemoglobinopathies
Genetic Diseases, Inborn

ClinicalTrials.gov processed this record on August 18, 2017