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Genetics of Alpha Thalassemia in Israeli Ethnic Groups

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ClinicalTrials.gov Identifier: NCT00159029
Recruitment Status : Completed
First Posted : September 12, 2005
Last Update Posted : August 10, 2017
Sponsor:
Information provided by (Responsible Party):
Deborah Rund, Hadassah Medical Organization

Brief Summary:

Alpha thalassemia causes mild anemia and is found in many ethnic groups. Usually it is found in regions where malaria is endemic. We have found that alpha thalassemia is common in Ashkenazim, whose countries of origin are in temperate climates.

We are analyzing the alpha globin genes of individuals of many ethnic groups and will compare to try to define the origin of thalassemia in these individuals of European extraction.


Condition or disease
Alpha Thalassemia

Detailed Description:

Alpha thalassemia causes mild anemia and is found in many ethnic groups. Usually it is found in regions where malaria is endemic. We have found that alpha thalassemia is common in Ashkenazim, whose countries of origin are in temperate climates.

We are analyzing the alpha globin polymorphisms to determine the haplotypes of individuals of many ethnic groups and will compare to try to define the origin of thalassemia in these individuals of European extraction.


Study Type : Observational
Actual Enrollment : 100 participants
Observational Model: Other
Time Perspective: Other
Official Title: Haplotype Analysis of Alpha Globin Genes in Israeli Ethnic Groups
Actual Study Start Date : April 1, 2004
Primary Completion Date : July 1, 2017
Study Completion Date : July 1, 2017

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Thalassemia
U.S. FDA Resources




Biospecimen Retention:   Samples With DNA
DNA isolated from peripheral blood.


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients who come to Hadassah Hospital for anemia with microcytosis who are found to have alpha thalassemia.
Criteria

Inclusion Criteria:

  • diagnosis of deletional alpha thalassemia

Exclusion Criteria:

  • under age 18

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00159029


Locations
Israel
Hadassah Medical Organization
Jerusalem, Israel
Sponsors and Collaborators
Deborah Rund
Investigators
Principal Investigator: Deborah Rund, MD Hadassah Medical Organization

Publications:
Responsible Party: Deborah Rund, Senior Hematologist, Hadassah Medical Organization
ClinicalTrials.gov Identifier: NCT00159029     History of Changes
Other Study ID Numbers: 152910-HMO-CTIL
First Posted: September 12, 2005    Key Record Dates
Last Update Posted: August 10, 2017
Last Verified: August 2017

Additional relevant MeSH terms:
Thalassemia
alpha-Thalassemia
Anemia, Hemolytic, Congenital
Anemia, Hemolytic
Anemia
Hematologic Diseases
Hemoglobinopathies
Genetic Diseases, Inborn