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Predictive Value of Dynamic Contrast Enhancement MRI on a Cerebral Tumor Response to Gamma Knife Treatment

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00156585
First Posted: September 12, 2005
Last Update Posted: January 15, 2015
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Martin Lepage, Université de Sherbrooke
  Purpose

Hypothesis: the pattern of MRI contrast enhancement after gadolinium injection is different in tumors that respond well to gamma knife.

We are going to acquire sequential T1-weighted images of brain lesions before, during and after injection of Gd-DTPA. This will be repeated before and after a treatment with gamma knife. We will then analyse our results to see if there are common enhancement characteristics between lesions that will respond well to the radiosurgery treatment. Response will be clinically assessed by tumor volume as determined by MRI approximately 4 to 6 months after treatment.


Condition
Cerebral Metastases

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Prospective Study of Predictive Value of Dynamic Contrast Enhancement Magnetic Resonance Imaging With Gadolinium on the Response of a Cerebral Tumor to a Treatment With Gamma Knife

Further study details as provided by Martin Lepage, Université de Sherbrooke:

Primary Outcome Measures:
  • MRI parameters [ Time Frame: Before treatment with the Gamma Knife ]
    Tumor volume, Ktrans, ve, time at maximum signal enhancement, maximum signal difference, ADC, basal T1 value


Enrollment: 31
Study Start Date: August 2005
Study Completion Date: April 2008
Primary Completion Date: April 2008 (Final data collection date for primary outcome measure)
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
oncology clinic
Criteria

Inclusion Criteria:

  • Patient with intracerebral lesion benign or malignant wich are not concerned by the exclusion criteria

Exclusion Criteria:

  • Pancranial radiotherapy
  • Residual postop lesion
  • Gliomas
  • Patients < 18 years old
  • Anterior allergic reaction to gadolinium
  • Claustrophobia.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00156585


Locations
Canada, Quebec
Faculté de médecine, Université de Sherbrooke
Sherbrooke, Quebec, Canada, J1H 5N4
Sponsors and Collaborators
Martin Lepage
Investigators
Principal Investigator: Jean Chenard, MD Université de Sherbrooke
  More Information

Responsible Party: Martin Lepage, MD, Université de Sherbrooke
ClinicalTrials.gov Identifier: NCT00156585     History of Changes
Other Study ID Numbers: 05-063
First Submitted: September 7, 2005
First Posted: September 12, 2005
Last Update Posted: January 15, 2015
Last Verified: January 2015

Keywords provided by Martin Lepage, Université de Sherbrooke:
cerebral metastases
dynamic contrast enhanced magnetic resonance imaging
DCE-MRI
gamma knife

Additional relevant MeSH terms:
Neoplasm Metastasis
Neoplastic Processes
Neoplasms
Pathologic Processes