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Skeletal Muscle Dysfunction in Heart Failure

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified September 2005 by Ullevaal University Hospital.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT00156234
First Posted: September 12, 2005
Last Update Posted: December 9, 2005
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborators:
Norwegian Health Association
Norwegian School of Sport Sciences
The Research Council of Norway
University of Oslo
Information provided by:
Ullevaal University Hospital
  Purpose

Patients suffering from congestive heart failure report reduced exercise capacity. This skeletal muscle dysfunction is also detectable when using small muscle groups which should not put any demand on the heart.

We hypothesize that congestive heart failure has systemic effects that causes the skeletal muscle dysfunction.


Condition Intervention
Heart Failure, Congestive Behavioral: One-knee extension ergometer

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single
Primary Purpose: Educational/Counseling/Training
Official Title: Training and Congestive Heart Failure

Resource links provided by NLM:


Further study details as provided by Ullevaal University Hospital:

Estimated Enrollment: 45
Study Start Date: March 2005
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   40 Years to 78 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Coronary Heart Failure
  • Ejection fraction <35%
  • NYHA 2-3
  • Spirometry FEV1 > 80%

Exclusion Criteria:

  • Cardiomyopathy
  • Transplantation candidate
  • Active malignancy
  • Restraining skeletal-muscular disease
  • Claudication in legs
  • Hospitalized last 30 days due to acute ischemic episode
  • Intravenous inotrope or vasodilatating drugs last 14 days prior to inclusion
  • AMI last 8 weeks prior to inclusion
  • Organized training last 4 months
  • Smoking on daily basis last 4 months
  • Creatinin < 150microliters/liter
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00156234


Locations
Norway
Institute for Experimental Medical Research Recruiting
Oslo, Norway, 0407
Contact: Ole M Sejersted, Professor    23 01 68 00 ext 47    o.m.sejersted@medisin.uio.no   
Contact: Per Kristian B Lunde, Post Doc    23 01 68 35 ext 47    p.k.lunde@medisin.uio.no   
Norwegian School of Sport Sciences Recruiting
Oslo, Norway, 0806
Contact: Jostein Hallén, Professor    23 26 23 14 ext 47    jostein.hallen@nih.no   
Contact: Gunnar Petersen, Ph.D student       gunnar.petersen@nih.no   
Sub-Investigator: Jostein Hallen, Professor         
Sponsors and Collaborators
Ullevaal University Hospital
Norwegian Health Association
Norwegian School of Sport Sciences
The Research Council of Norway
University of Oslo
Investigators
Study Chair: Ole M Sejersted, Professor Institute for Experimental Medical Research, Ullevaal University Hospital
Study Director: Per Kristian B Lunde, Post Doc Institute for Experimental Medical Research, Ullevaal University Hospital
Study Director: Ivar Sjaastad, Post Doc Institute for Experimental Medical Research, Ullevaal University Hospital
Study Chair: Jostein Hallen, Professor Norwegian School of Sport Sciences
Principal Investigator: Morten Munkvik, Ph.D student Institute for Experimental Medical Research, Ullevaal University Hospital
Principal Investigator: Tommy A Rehn, Vit.ass. Institute for Experimental Medical Research, Ullevaal University Hospital
Principal Investigator: Gunnar S Petersen, Ph.D student Norwegian School of Sport Sciences
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
ClinicalTrials.gov Identifier: NCT00156234     History of Changes
Other Study ID Numbers: TRUST-001
Helse Øst
Helse og rehabilitering
First Submitted: September 8, 2005
First Posted: September 12, 2005
Last Update Posted: December 9, 2005
Last Verified: September 2005

Additional relevant MeSH terms:
Heart Failure
Heart Diseases
Cardiovascular Diseases