MR Scanning of Very Young Children With Severe Developmental Disorders
This study has been completed.
Sponsor:
UMC Utrecht
Collaborators:
Netherlands Organisation for Scientific Research
The Dutch Brain Foundation
Information provided by:
UMC Utrecht
ClinicalTrials.gov Identifier:
NCT00156221
First received: September 8, 2005
Last updated: NA
Last verified: September 2005
History: No changes posted
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Purpose
The specific is to study the MR morphologic and spectroscopic brain correlates and predictors of development in children with severe developmental disorders (autistic spectrum disorders and/or mental retardation and/or language disorders). Given the frequently observed association of autism with known medical conditions, particularly in cases with comorbid mental retardation and in cases with atypical autism (Rutter et al., 1994; Gillberg, 1995), children with suspected autism or related developmental disorders will be asked to participate in an extensive state of the art laboratory work-up which includes T1 and T2 weighted MRI of the brain. MRI data will be analyzed both qualitatively, looking for focal abnormalities and degree of myelination, and quantitatively, measuring volumes of total brain, cerebellum, ventricles and grey and white matter. For research purposes, the work-up will be supplied with proton Magnetic Resonance Spectroscopy (MRS) of the brain. This data set provides the opportunity to chart brain-behavior relationships in young children with suspected autism and related PDD cross-sectionally.
| Condition |
|---|
|
Autism Mental Retardation Language Disorder |
| Study Type: | Observational |
| Study Design: | Observational Model: Natural History Time Perspective: Cross-Sectional Time Perspective: Retrospective/Prospective |
| Official Title: | MR Scanning of Very Young Children With Severe Developmental Disorders (Autistic Spectrum Disorders and/or Mental Retardation and/or Language Disorders) |
Resource links provided by NLM:
Genetics Home Reference related topics:
CASK-related intellectual disability
SYNGAP1-related intellectual disability
MedlinePlus related topics:
Developmental Disabilities
U.S. FDA Resources
Further study details as provided by UMC Utrecht:
Eligibility| Ages Eligible for Study: | 18 Months to 7 Years (Child) |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Criteria
Inclusion Criteria:
- Age 18 months to 7 years
- Diagnosis of autism spectrum disorder, a language disorder or mental retardation
Exclusion Criteria:
- Significant motor or sensory impairment
- Major physical abnormalities
- History of serious head injury
- Identifiable neurologic disorder
- Metal implants
- Contraindication for MRI
Contacts and Locations
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To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00156221
Please refer to this study by its ClinicalTrials.gov identifier: NCT00156221
Locations
| Netherlands | |
| UMC Utrecht | |
| Utrecht, Netherlands, 3508 GA | |
Sponsors and Collaborators
UMC Utrecht
Netherlands Organisation for Scientific Research
The Dutch Brain Foundation
Investigators
| Study Chair: | Herman van Engeland, PhD, MD | UMC Utrecht |
| Principal Investigator: | Mijke Zeegers, Msc | UMC Utrecht |
More Information
| ClinicalTrials.gov Identifier: | NCT00156221 History of Changes |
| Other Study ID Numbers: | METC UMC Utrecht 99/184 |
| Study First Received: | September 8, 2005 |
| Last Updated: | September 8, 2005 |
| Health Authority: | Netherlands: The Central Committee on Research Involving Human Subjects (CCMO) |
Keywords provided by UMC Utrecht:
|
Autism MRI Developmental Disorders |
Additional relevant MeSH terms:
|
Language Disorders Disease Developmental Disabilities Intellectual Disability Pathologic Processes Neurodevelopmental Disorders |
Mental Disorders Neurobehavioral Manifestations Neurologic Manifestations Nervous System Diseases Signs and Symptoms Communication Disorders |
ClinicalTrials.gov processed this record on September 23, 2016