The Gene Expression Patterns in the Peripheral White Blood Cells of Type 2 Diabetic Patients
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|ClinicalTrials.gov Identifier: NCT00155922|
Recruitment Status : Unknown
Verified September 2005 by National Taiwan University Hospital.
Recruitment status was: Recruiting
First Posted : September 12, 2005
Last Update Posted : December 14, 2006
|Condition or disease|
|Diabetes Mellitus, Type 2 Atherosclerosis|
Cardiovascular events are the leading cause of death in developed countries worldwide, including Taiwan. Type 2 diabetes mellitus (T2DM), previously considered merely as one of the risk factors, has been recently unanimously accepted to be coronary artery disease-equivalent. How T2DM may lead to accelerated atherosclerosis remains obscure.
Hyperglycemia with or without hyperinsulinemia may lead to higher oxidative stress and generalized inflammation. The oxidative stress and inflammation may play a significant role in the pathogenesis in diabetic complications, including micro- and macro-vascular complications. Macrophages together with T-lymphocytes are the earliest cell-types found in fatty-streaks, the earliest atherosclerotic lesions. Macrophages are also well known cellular mediators of oxidative stress and inflammation. Therefore, it is plausible to hypothesize that macrophages play a crucial role in the pathogenesis of atherosclerosis in patients with T2DM. In addition, the other cell types of the peripheral white blood cells (WBC), such as neutrophils, have been shown to be intimately related to acute coronary syndrome. Therefore, the study on the biology of peripheral WBCs may tell us something about the pathophysiology of diabetic macro-vascular complications.
- Normal control: fasting plasma glucose (FPG) less than 126 mg/dl.
T2DM: FPG ＞＝126 mg/dl.
- Group 1 (good glycemic control): hemoglobin A1c (HbA1c) ＜＝ 7% in the past 6 months
- Group 2 (poor glycemic control): HbA1c ＞＝ 8% in the past 6 months
- Blood sample will be collected at baseline and after aggressive control.
|Study Type :||Observational|
|Estimated Enrollment :||100 participants|
|Observational Model:||Case Control|
|Observational Model:||Natural History|
|Official Title:||The Gene Expression Patterns in the Peripheral White Blood Cells of Type 2 Diabetic Patients, Special Relevance to Atherosclerosis|
|Study Start Date :||November 2003|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00155922
|Contact: Wei-Shiung Yang, MD, PhD||886-2-2312-3456 ext firstname.lastname@example.org|
|National Taiwan University Hospital||Recruiting|
|Taipei, Taiwan, 10012|
|Contact: Wei-Shiung Yang, MD, PhD 886-2-23123456 ext 7258 email@example.com|
|Principal Investigator:||Wei-Shiung Yang, MD, PhD||National Taiwan University Hospital|