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Immunologic Factors in Reflux Esophagitis and Barrett’s Esophagus

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00155805
Recruitment Status : Unknown
Verified February 2004 by National Taiwan University Hospital.
Recruitment status was:  Recruiting
First Posted : September 12, 2005
Last Update Posted : November 28, 2005
Information provided by:
National Taiwan University Hospital

Brief Summary:
By using combination of the expression of COX-2 and NOS and immunologic reaction in the esophagus with manometry of LES and cruel diaphragm and 24 hr esophageal pH monitoring to investigate the mechanisms and to make a new and more clinically applicable clarification of these reflux diseases will be valuable in the clinical management and prevention. We will perform the following works and complete the objectives: 1) comparing the difference of immuno-inflammatory reactions among NERD, reflux esophagitis and Barrett’s esophagus; 2) the different expression of PGs & COX-2 in functional heartburn, hiatus hernia, NERD, reflux disease and Barrett’s esophagus; determining the subtype of EP receptor (EP1~4); 3) determining and comparing the expression of NOS in the esophagus; 4) investigating the role of ROS in the esophagus; 5) in correlating cytokine, COX-2 and NOS with LESP, TLESR, diaphragm EMG and 24-hour esophageal pH ; 6) the difference of expression of cytokine, atrophic gastritis and Hp in gastric mucosa, in correlating with intragastric acid status, among functional heartburn, hiatus hernia, NERD, erosive esophagitis and Barrett’s esophagus; to determine whether should eradicate Hp in reflux esophageal disease; 7) the effects of lipid peroxidation related immunologic reaction, with relation to COX-2 and NOS, in the inflammatory activity and esophageal carcinogenesis of esophagus; 8) the effects of cytokines, COX-2 and NOS on the apoptosis in these reflux esophageal diseases; 9) integrating immuno-inflamatory reaction, COX-2, NOS with manometry of LES and diaphragm, and 24-hour pH monitoring and intragastric pH to newly clarify GERD into evidence based categories.

Condition or disease
Reflux Esophagitis Hiatal Hernia

  Show Detailed Description

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Study Type : Observational
Enrollment : 90 participants
Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Cross-Sectional
Time Perspective: Prospective
Official Title: Immunologic Factors Correlating With Cyclooxygenase and Nitric Oxide Synthase in Reflux Esophagitis and Barrett’s Esophagus
Study Start Date : February 2004
Study Completion Date : December 2006

Resource links provided by the National Library of Medicine

MedlinePlus related topics: GERD

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • age between 18-80
  • endoscopy diagnosed esophagitis
  • GERD questionnaire screened nonerosive reflux disease

Exclusion Criteria:

  • A history of esophageal, gastric or abdominal surgery.
  • Gastric or esophageal cancer.
  • Esophageal varices.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00155805

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Contact: Bor-Ru Lin, M.D. 886-2-23123456 ext 7788

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National Taiwan University Hospital Recruiting
Taipei, Taiwan, 10016
Contact: Bor-Ru Lin, M.D.    886-2-23123456 ext 7788   
Sponsors and Collaborators
National Taiwan University Hospital
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Principal Investigator: Bor-Ru Lin, M.D. National Taiwan University Hospital

Layout table for additonal information Identifier: NCT00155805     History of Changes
Other Study ID Numbers: 9200200605
First Posted: September 12, 2005    Key Record Dates
Last Update Posted: November 28, 2005
Last Verified: February 2004

Keywords provided by National Taiwan University Hospital:
Gastroesophageal reflux disease
reflux esophagitis
nonerosive reflux disease
Barrett’s esophagus
hiatus hernia
lower esophageal sphincter pressure
24 hours esophageal pH monitor
Helicobacter pylori

Additional relevant MeSH terms:
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Immunologic Factors
Barrett Esophagus
Gastroesophageal Reflux
Esophagitis, Peptic
Hernia, Hiatal
Pathological Conditions, Anatomical
Esophageal Motility Disorders
Deglutition Disorders
Esophageal Diseases
Gastrointestinal Diseases
Digestive System Diseases
Precancerous Conditions
Peptic Ulcer
Duodenal Diseases
Intestinal Diseases
Stomach Diseases
Hernia, Diaphragmatic
Physiological Effects of Drugs