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Genomewide Screening of Pathological Myopia

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified April 2010 by National Taiwan University Hospital.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT00155753
First Posted: September 12, 2005
Last Update Posted: June 9, 2010
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
National Taiwan University Hospital
  Purpose
The purpose of this study is to evaluate the possible candidate gene of pathological myopia

Condition
Pathological Myopia

Study Type: Observational
Study Design: Observational Model: Case Control
Official Title: Genomewide Screening of Pathological Myopia

Further study details as provided by National Taiwan University Hospital:

Biospecimen Retention:   Samples With DNA
DNA extracted from blood

Estimated Enrollment: 600
Study Start Date: August 2002
Estimated Study Completion Date: August 2010
Estimated Primary Completion Date: August 2010 (Final data collection date for primary outcome measure)
Detailed Description:

High myopia (pathological myopia) is caused by excessive axial elongation that primarily involves the ora-equatorial area and the posterior pole. Peripheral fundus changes and posterior staphyloma formation are ophthalmoscopic evidences of this process. Pathological myopia often accompanied by glaucoma, cataracts, macular degeneration, and retinal detachment, leading to blindness when the damage to the retina is extremely severe. Population and family studies in Chinese have provided evidence for a genetic component to pathologic myopia. Children of myopic parents are more likely to have myopia than are children of nonmyopic parents. The ocular components (axial length, anterior chamber depth, and corneal curvature) and refractive errors of MZ twins are more closely aligned than are those of DZ twins.

Therefore, it is possible to search a potential candidate gene for myopia through the genomic study of pathological myopia.

  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Taiwanese
Criteria

Inclusion Criteria:

  • They are unrelated Chinese subjects with high myopia ≦-6.00D. The diagnosis of myopia is determined by the refractive error. Anisometropic individuals, with a refractive error of ≦-6.00 D for one eye and ≦-6.00 D for the other eye, with at least a 2-D difference between the two eyes, are considered unaffected.

Exclusion Criteria:

  • Individuals are excluded if there is known ocular disease or insult that could predispose to myopia, such as retinopathy of prematurity or early-age media opacification, or if they had a known genetic disease associated with myopia, such as Stickler or Marfan syndrome.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00155753


Contacts
Contact: Yung-Feng Shih, MD 886-2-23123456 ext 5184 yfshih@ha.mc.ntu.edu.tw

Locations
Taiwan
National Taiwan University Hospital Recruiting
Taipei, Taiwan, 100
Contact: Yung-Feng Shih, MD    886-2-23123456 ext 5184    yfshih@ha.mc.ntu.edu.tw   
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
Principal Investigator: Yung-Feng Shih, MD National Taiwan University Hospiyal
  More Information

Responsible Party: Yung-Feng Shih, National Taiwan University Hospital
ClinicalTrials.gov Identifier: NCT00155753     History of Changes
Other Study ID Numbers: 9100205245
First Submitted: September 9, 2005
First Posted: September 12, 2005
Last Update Posted: June 9, 2010
Last Verified: April 2010

Keywords provided by National Taiwan University Hospital:
pathological myopia, genomic

Additional relevant MeSH terms:
Myopia
Myopia, Degenerative
Refractive Errors
Eye Diseases