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Genomewide Screening of Pathological Myopia

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ClinicalTrials.gov Identifier: NCT00155753
Recruitment Status : Unknown
Verified April 2010 by National Taiwan University Hospital.
Recruitment status was:  Recruiting
First Posted : September 12, 2005
Last Update Posted : June 9, 2010
Sponsor:
Information provided by:
National Taiwan University Hospital

Study Description
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Brief Summary:
The purpose of this study is to evaluate the possible candidate gene of pathological myopia

Condition or disease
Pathological Myopia

Detailed Description:

High myopia (pathological myopia) is caused by excessive axial elongation that primarily involves the ora-equatorial area and the posterior pole. Peripheral fundus changes and posterior staphyloma formation are ophthalmoscopic evidences of this process. Pathological myopia often accompanied by glaucoma, cataracts, macular degeneration, and retinal detachment, leading to blindness when the damage to the retina is extremely severe. Population and family studies in Chinese have provided evidence for a genetic component to pathologic myopia. Children of myopic parents are more likely to have myopia than are children of nonmyopic parents. The ocular components (axial length, anterior chamber depth, and corneal curvature) and refractive errors of MZ twins are more closely aligned than are those of DZ twins.

Therefore, it is possible to search a potential candidate gene for myopia through the genomic study of pathological myopia.

Study Design
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Study Type : Observational
Estimated Enrollment : 600 participants
Observational Model: Case-Control
Official Title: Genomewide Screening of Pathological Myopia
Study Start Date : August 2002
Estimated Primary Completion Date : August 2010
Estimated Study Completion Date : August 2010

Resource links provided by the National Library of Medicine


Groups and Cohorts
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Outcome Measures
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Biospecimen Retention:   Samples With DNA
DNA extracted from blood

Eligibility Criteria
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Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Taiwanese
Criteria

Inclusion Criteria:

  • They are unrelated Chinese subjects with high myopia ≦-6.00D. The diagnosis of myopia is determined by the refractive error. Anisometropic individuals, with a refractive error of ≦-6.00 D for one eye and ≦-6.00 D for the other eye, with at least a 2-D difference between the two eyes, are considered unaffected.

Exclusion Criteria:

  • Individuals are excluded if there is known ocular disease or insult that could predispose to myopia, such as retinopathy of prematurity or early-age media opacification, or if they had a known genetic disease associated with myopia, such as Stickler or Marfan syndrome.
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00155753


Contacts
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Contact: Yung-Feng Shih, MD 886-2-23123456 ext 5184 yfshih@ha.mc.ntu.edu.tw

Locations
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Taiwan
National Taiwan University Hospital Recruiting
Taipei, Taiwan, 100
Contact: Yung-Feng Shih, MD    886-2-23123456 ext 5184    yfshih@ha.mc.ntu.edu.tw   
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
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Principal Investigator: Yung-Feng Shih, MD National Taiwan University Hospiyal
More Information
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Responsible Party: Yung-Feng Shih, National Taiwan University Hospital
ClinicalTrials.gov Identifier: NCT00155753    
Other Study ID Numbers: 9100205245
First Posted: September 12, 2005    Key Record Dates
Last Update Posted: June 9, 2010
Last Verified: April 2010
Keywords provided by National Taiwan University Hospital:
pathological myopia, genomic
Additional relevant MeSH terms:
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Myopia
Myopia, Degenerative
Refractive Errors
Eye Diseases