Genomewide Screening of Pathological Myopia
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|ClinicalTrials.gov Identifier: NCT00155753|
Recruitment Status : Unknown
Verified April 2010 by National Taiwan University Hospital.
Recruitment status was: Recruiting
First Posted : September 12, 2005
Last Update Posted : June 9, 2010
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|Condition or disease|
High myopia (pathological myopia) is caused by excessive axial elongation that primarily involves the ora-equatorial area and the posterior pole. Peripheral fundus changes and posterior staphyloma formation are ophthalmoscopic evidences of this process. Pathological myopia often accompanied by glaucoma, cataracts, macular degeneration, and retinal detachment, leading to blindness when the damage to the retina is extremely severe. Population and family studies in Chinese have provided evidence for a genetic component to pathologic myopia. Children of myopic parents are more likely to have myopia than are children of nonmyopic parents. The ocular components (axial length, anterior chamber depth, and corneal curvature) and refractive errors of MZ twins are more closely aligned than are those of DZ twins.
Therefore, it is possible to search a potential candidate gene for myopia through the genomic study of pathological myopia.
|Study Type :||Observational|
|Estimated Enrollment :||600 participants|
|Official Title:||Genomewide Screening of Pathological Myopia|
|Study Start Date :||August 2002|
|Estimated Primary Completion Date :||August 2010|
|Estimated Study Completion Date :||August 2010|
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:||Child, Adult, Older Adult|
|Sexes Eligible for Study:||All|
|Accepts Healthy Volunteers:||Yes|
|Sampling Method:||Non-Probability Sample|
- They are unrelated Chinese subjects with high myopia ≦-6.00D. The diagnosis of myopia is determined by the refractive error. Anisometropic individuals, with a refractive error of ≦-6.00 D for one eye and ≦-6.00 D for the other eye, with at least a 2-D difference between the two eyes, are considered unaffected.
- Individuals are excluded if there is known ocular disease or insult that could predispose to myopia, such as retinopathy of prematurity or early-age media opacification, or if they had a known genetic disease associated with myopia, such as Stickler or Marfan syndrome.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00155753
|Contact: Yung-Feng Shih, MD||886-2-23123456 ext email@example.com|
|National Taiwan University Hospital||Recruiting|
|Taipei, Taiwan, 100|
|Contact: Yung-Feng Shih, MD 886-2-23123456 ext 5184 firstname.lastname@example.org|
|Principal Investigator:||Yung-Feng Shih, MD||National Taiwan University Hospiyal|
|Responsible Party:||Yung-Feng Shih, National Taiwan University Hospital|
|Other Study ID Numbers:||
|First Posted:||September 12, 2005 Key Record Dates|
|Last Update Posted:||June 9, 2010|
|Last Verified:||April 2010|
pathological myopia, genomic