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A Study on Etiological Factors of Schizophrenia

This study has been terminated.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00155636
First Posted: September 12, 2005
Last Update Posted: December 9, 2005
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
National Taiwan University Hospital
  Purpose
This PPG entitled “A Study on Etiological Factors of Schizophrenia” (SEFOS) focuses on searching for the separate etiological factors under the understanding that schizophrenia is a complex disorder. Multifactorial model has been most often proposed as the etiological model. Up to now, fragmented knowledge of etiological factors, including genetic factor and environmental insults were reported in literature, and a two-strike hypothesis has been proposed. This PPG of SEFOS formulates a dynamic etiological hypothesis of schizophrenia. Specific, however heterogeneous, genes are hypothesized to be located in chromosome 1q, 6P, 8P, 15q, and 22q; specific environmental insults or stress are hypothesized to be acting in the vulnerable brain a long different stages of biological and/or psychological development. The interaction of specific genes and specific environment insults/stress along different stages of development will result in specific neurobiological abnormalities as shown in neuropsychological, neurophysiological and neurochemical/neuroimaging abnormalities. For this hypothesis testing, this PPG of SEFOS designs 3 projects of: (1) A Study on Neurobiology of Schizophrenia; (2) A Study on Environmental insults/stress of schizophrenia; and (3) Molecular Genetics Study of Schizophrenia. Project No.1 aims at finding different levels of neurobiological and anatomical abnormalities; Project No.2 aims at finding different levels of environmental insults/ stress; Project No.3 aims at locating vulnerability genes in different chromosome regions. A core unit for administrative integration, for case/family recruitment and statistical analysis is also designed. The dynamic etiological complex will be explored under multivariate statistical analysis. This PPG of SEFOS adopts multidisciplinary approach including clinical psychiatrists, psychopathologists, neuropsychologist, neurophysiologist, neuroimaging (magnetic resonance imaging) specialist, genetic epidemiologist, molecular genetic specialist, genetic statistician, and biostatisticians. This team has sound mutual trust base on the experience of being working together and attending regular research meeting for the part several years under the leadership of the principal investigator of this PPG.

Condition
Schizophrenia

Study Type: Observational
Study Design: Observational Model: Defined Population
Time Perspective: Longitudinal
Time Perspective: Retrospective/Prospective
Official Title: A Study on Etiological Factors of Schizophrenia

Resource links provided by NLM:


Further study details as provided by National Taiwan University Hospital:

Estimated Enrollment: 1056
Study Start Date: January 2002
Estimated Study Completion Date: December 2005
  Show Detailed Description

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Schizophrenia
  • There are two schizophrenia sib-paired children, one schizophrenia parent and the other one should be normal

Exclusion Criteria:

  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00155636


Sponsors and Collaborators
National Taiwan University Hospital
Investigators
Principal Investigator: Hai-Gwo Hwu, Professor National Taiwan University
  More Information

ClinicalTrials.gov Identifier: NCT00155636     History of Changes
Other Study ID Numbers: 5287
NHRI-EX91-9113PP
First Submitted: September 9, 2005
First Posted: September 12, 2005
Last Update Posted: December 9, 2005
Last Verified: January 2002

Keywords provided by National Taiwan University Hospital:
Schizophrenia

Additional relevant MeSH terms:
Schizophrenia
Schizophrenia Spectrum and Other Psychotic Disorders
Mental Disorders