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A Study on Etiological Factors of Schizophrenia

This study has been terminated.
Information provided by:
National Taiwan University Hospital Identifier:
First received: September 9, 2005
Last updated: November 25, 2005
Last verified: January 2002
This PPG entitled “A Study on Etiological Factors of Schizophrenia” (SEFOS) focuses on searching for the separate etiological factors under the understanding that schizophrenia is a complex disorder. Multifactorial model has been most often proposed as the etiological model. Up to now, fragmented knowledge of etiological factors, including genetic factor and environmental insults were reported in literature, and a two-strike hypothesis has been proposed. This PPG of SEFOS formulates a dynamic etiological hypothesis of schizophrenia. Specific, however heterogeneous, genes are hypothesized to be located in chromosome 1q, 6P, 8P, 15q, and 22q; specific environmental insults or stress are hypothesized to be acting in the vulnerable brain a long different stages of biological and/or psychological development. The interaction of specific genes and specific environment insults/stress along different stages of development will result in specific neurobiological abnormalities as shown in neuropsychological, neurophysiological and neurochemical/neuroimaging abnormalities. For this hypothesis testing, this PPG of SEFOS designs 3 projects of: (1) A Study on Neurobiology of Schizophrenia; (2) A Study on Environmental insults/stress of schizophrenia; and (3) Molecular Genetics Study of Schizophrenia. Project No.1 aims at finding different levels of neurobiological and anatomical abnormalities; Project No.2 aims at finding different levels of environmental insults/ stress; Project No.3 aims at locating vulnerability genes in different chromosome regions. A core unit for administrative integration, for case/family recruitment and statistical analysis is also designed. The dynamic etiological complex will be explored under multivariate statistical analysis. This PPG of SEFOS adopts multidisciplinary approach including clinical psychiatrists, psychopathologists, neuropsychologist, neurophysiologist, neuroimaging (magnetic resonance imaging) specialist, genetic epidemiologist, molecular genetic specialist, genetic statistician, and biostatisticians. This team has sound mutual trust base on the experience of being working together and attending regular research meeting for the part several years under the leadership of the principal investigator of this PPG.


Study Type: Observational
Study Design: Observational Model: Defined Population
Time Perspective: Longitudinal
Time Perspective: Retrospective/Prospective
Official Title: A Study on Etiological Factors of Schizophrenia

Resource links provided by NLM:

Further study details as provided by National Taiwan University Hospital:

Estimated Enrollment: 1056
Study Start Date: January 2002
Estimated Study Completion Date: December 2005
  Show Detailed Description


Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Schizophrenia
  • There are two schizophrenia sib-paired children, one schizophrenia parent and the other one should be normal

Exclusion Criteria:

  Contacts and Locations
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Please refer to this study by its identifier: NCT00155636

Sponsors and Collaborators
National Taiwan University Hospital
Principal Investigator: Hai-Gwo Hwu, Professor National Taiwan University
  More Information Identifier: NCT00155636     History of Changes
Other Study ID Numbers: 5287
Study First Received: September 9, 2005
Last Updated: November 25, 2005

Keywords provided by National Taiwan University Hospital:

Additional relevant MeSH terms:
Schizophrenia Spectrum and Other Psychotic Disorders
Mental Disorders processed this record on September 19, 2017