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The Role of CGRPand Nociceptin in Migraine
The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified June 2005 by National Taiwan University Hospital.
Recruitment status was: Recruiting
Recruitment status was: Recruiting
Sponsor:
National Taiwan University Hospital
Information provided by:
National Taiwan University Hospital
ClinicalTrials.gov Identifier:
NCT00155129
First received: September 9, 2005
Last updated: NA
Last verified: June 2005
History: No changes posted
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Purpose
The release of the neuropeptide calcitonin gene-related peptide (CGRP) is thought to play a causative role in migraine. Nociceptin immunoreactivity and ORL-1 mRNA have been detected in human trigeminal ganglia where it was co-localized with CGRP. It may play a role in migraine pathogenesis. We are collecting the blood samples of migraineurs for analysis of these neuropeptides.
| Condition |
|---|
| Migraine Headache |
| Study Type: | Observational |
| Study Design: | Observational Model: Defined Population Primary Purpose: Screening Time Perspective: Cross-Sectional Time Perspective: Prospective |
| Official Title: | The Role of Calcitonin Gene-Related Peptide(CGRP)and Nociceptin in the Pathogenesis of Migraine |
Resource links provided by NLM:
Further study details as provided by National Taiwan University Hospital:
| Estimated Enrollment: | 200 |
| Study Start Date: | January 2005 |
| Estimated Study Completion Date: | June 2005 |
The release of the neuropeptide calcitonin gene-related peptide (CGRP) is thought to play a causative role in migraine. Nociceptin immunoreactivity and ORL-1 mRNA have been detected in human trigeminal ganglia where it was co-localized with CGRP. It may play a role in migraine pathogenesis. We are collecting the blood samples of migraineurs for analysis of these neuropeptides.
Eligibility| Ages Eligible for Study: | 3 Years to 50 Years (Child, Adult) |
| Sexes Eligible for Study: | All |
| Accepts Healthy Volunteers: | Yes |
Criteria
Inclusion Criteria: patients with headache -
Exclusion Criteria: fever, congenital anomaly, CNS organic lesions
Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00155129
Please refer to this study by its ClinicalTrials.gov identifier: NCT00155129
Contacts
| Contact: Pi-Chuan Fan, MD | pcfan@ntumc.org | ||
| Contact: Li-Chu Chiou, PhD |
Locations
| Taiwan | |
| Department of Pediatrics | Recruiting |
| Taipei, Taiwan | |
| Contact: Pi-Chuan Fan, MD 886-2-23123456 ext 5135 pcfan@ntumc.org | |
| Principal Investigator: Pi-Chuan Fan, MD | |
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
| Principal Investigator: | Pi-Chuan Fan | Department of Pediatric, NTUH |
More Information
| ClinicalTrials.gov Identifier: | NCT00155129 History of Changes |
| Other Study ID Numbers: |
9361701099 |
| Study First Received: | September 9, 2005 |
| Last Updated: | September 9, 2005 |
Keywords provided by National Taiwan University Hospital:
|
migraine CGRP nociceptin |
Additional relevant MeSH terms:
|
Migraine Disorders Headache Headache Disorders, Primary Headache Disorders Brain Diseases Central Nervous System Diseases Nervous System Diseases Pain Neurologic Manifestations Signs and Symptoms Nociceptin |
Calcitonin Gene-Related Peptide Nocistatin Vasodilator Agents Analgesics, Opioid Narcotics Central Nervous System Depressants Physiological Effects of Drugs Analgesics Sensory System Agents Peripheral Nervous System Agents |
ClinicalTrials.gov processed this record on July 18, 2017