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Effect of Polymorphisms in the IL-1 Gene Complex on the Development of Chronic Hepatitis and Hepatocellular Carcinoma

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified July 2005 by National Taiwan University Hospital.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT00155103
First Posted: September 12, 2005
Last Update Posted: March 21, 2007
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
National Science Council, Taiwan
Information provided by:
National Taiwan University Hospital
  Purpose
The purpose of this study is to determine the effect of polymorphisms in the IL-1 gene complex on the development of chronic hepatitis and hepatocellular carcinoma.

Condition
Hepatitis B Carcinoma, Hepatocellular Polymorphism, Genetic

Study Type: Observational
Study Design: Observational Model: Case Control
Observational Model: Natural History
Time Perspective: Longitudinal
Time Perspective: Retrospective
Official Title: Effect of Polymorphisms in the IL-1 Gene Complex on the Development of Chronic Hepatitis and Hepatocellular Carcinoma

Resource links provided by NLM:


Further study details as provided by National Taiwan University Hospital:

Estimated Enrollment: 1600
Study Start Date: August 2004
Detailed Description:
We analyzed single-nucleotide polymorphisms in the genes for interleukin-1a, interleukin-1b, interleukin-1-receptor antagonist, interleukin-1-receptor type I, and interleukin-1-receptor type II in 400 normal control and patients (chronic hepatitis and hepatocellular carcinoma). Genotypes were tested for an association with development of chronic hepatitis and hepatocellular carcinoma by multivariable analysis. A second cohort of 1200 normal control and patients (chronic hepatitis and hepatocellular carcinoma) was independently analyzed for the genotype associations identified in the first cohort.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Normal controls
  • Cases of chronic hepatitis and hepatocellular carcinoma

Exclusion Criteria:

  • Pregnant women
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00155103


Contacts
Contact: Li-Hui Tseng, M.D., Ph.D. +886-2-2312-3456 ext 7437 htseng@ha.mc.ntu.edu.tw
Contact: Fang-Yu Chan, B.A. +886-2-2312-3456 ext 7440 p93448006@ntu.edu.tw

Locations
Taiwan
Department of Medical Genetics; National Taiwan University Hospital Recruiting
Taipei, Taiwan, 100
Contact: Li-Hui Tseng, M.D., Ph.D.    +886-2-2312-3456 ext 7437    htseng@ha.mc.ntu.edu.tw   
Contact: Fang-Yu Chan, B.A.    +886-2-2312-3456 ext 7440    p93448006@ntu.edu.tw   
Principal Investigator: Fang-Yu Chan, B.A.         
Sponsors and Collaborators
National Taiwan University Hospital
National Science Council, Taiwan
Investigators
Study Chair: Li-Hui Tseng, M.D., Ph.D. National Taiwan University Hospital
  More Information

ClinicalTrials.gov Identifier: NCT00155103     History of Changes
Other Study ID Numbers: 9361700927
NSC 93-2314-B-002-226
First Submitted: September 9, 2005
First Posted: September 12, 2005
Last Update Posted: March 21, 2007
Last Verified: July 2005

Keywords provided by National Taiwan University Hospital:
Hepatitis B
Carcinoma, Hepatocellular
Polymorphism, Genetic

Additional relevant MeSH terms:
Carcinoma, Hepatocellular
Carcinoma
Hepatitis
Hepatitis A
Hepatitis, Chronic
Hepatitis B
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Neoplasms
Liver Diseases
Digestive System Diseases
Hepatitis, Viral, Human
Virus Diseases
Enterovirus Infections
Picornaviridae Infections
RNA Virus Infections
Adenocarcinoma
Liver Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Hepadnaviridae Infections
DNA Virus Infections