Effect of Polymorphisms in the IL-1 Gene Complex on the Development of Chronic Hepatitis and Hepatocellular Carcinoma
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ClinicalTrials.gov Identifier: NCT00155103
Verified July 2005 by National Taiwan University Hospital. Recruitment status was: Recruiting
We analyzed single-nucleotide polymorphisms in the genes for interleukin-1a, interleukin-1b, interleukin-1-receptor antagonist, interleukin-1-receptor type I, and interleukin-1-receptor type II in 400 normal control and patients (chronic hepatitis and hepatocellular carcinoma). Genotypes were tested for an association with development of chronic hepatitis and hepatocellular carcinoma by multivariable analysis. A second cohort of 1200 normal control and patients (chronic hepatitis and hepatocellular carcinoma) was independently analyzed for the genotype associations identified in the first cohort.
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Ages Eligible for Study:
18 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Cases of chronic hepatitis and hepatocellular carcinoma
Keywords provided by National Taiwan University Hospital:
Hepatitis B Carcinoma, Hepatocellular
Additional relevant MeSH terms:
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Digestive System Diseases
Hepatitis, Viral, Human
RNA Virus Infections
Digestive System Neoplasms
Neoplasms by Site
DNA Virus Infections