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Additional Minocycline Pleurodesis After Thoracoscopic Procedures for Primary Spontaneous Pneumothorax

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00154895
Recruitment Status : Unknown
Verified June 2001 by National Taiwan University Hospital.
Recruitment status was:  Recruiting
First Posted : September 12, 2005
Last Update Posted : October 20, 2005
National Science Council, Taiwan
Information provided by:
National Taiwan University Hospital

Brief Summary:
To test if additional minocycline pleurodesis after thoracoscopic procedures can reduce the rates of ipsilateral recurrence for patients with primary spontaneous pneumothorax.

Condition or disease Intervention/treatment Phase
Pneumothorax Drug: intrapleural minocycline instillation Phase 3

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Study Type : Interventional  (Clinical Trial)
Enrollment : 200 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Phase III Study of Additional Minocycline Pleurodesis After Video-Assisted Thoracoscopic Surgery for Primary Spontaneous Pneumothorax
Study Start Date : June 2001
Study Completion Date : March 2005

Primary Outcome Measures :
  1. The primary end point was rates of ipsilateral recurrence after the operation.

Secondary Outcome Measures :
  1. safety of minocycline
  2. early postoperative results of minocycline
  3. long-term complication of minocycline
  4. long-term effect on pulmonary function of minocycline pleurodesis

Information from the National Library of Medicine

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Ages Eligible for Study:   10 Years to 50 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • All patients requiring VATS caused by recurrent, persistent, or contralateral spontaneous pneumothorax as well as by spontaneous hemopneumothorax were eligible for this study.

Exclusion Criteria:

  • greater than 50 years of age, with underlying pulmonary disease, previous ipsilateral thoracic operation, allergy to tetracycline or minocycline, and unwilling to receive randomization.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00154895

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Contact: Jin-Shing Chen, MD, PhD 886-2-23123456 ext 5178
Contact: Yung-Chie Lee, MD, PhD 886-2-23123456 ext 5070

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Yung-Chie Lee Recruiting
Taipei, Taiwan, 100
Contact: Jin-Shing Chen, MD, PhD    886-2-23123456 ext 5178   
Sub-Investigator: Jin-Shing Chen, MD, PhD         
Principal Investigator: Yung-Chie Lee, MD, PhD         
Sponsors and Collaborators
National Taiwan University Hospital
National Science Council, Taiwan
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Study Chair: Yung-Chie Lee, MD, PhD Natinal Taiwan University Hospital
Layout table for additonal information Identifier: NCT00154895    
Other Study ID Numbers: 921204
First Posted: September 12, 2005    Key Record Dates
Last Update Posted: October 20, 2005
Last Verified: June 2001
Keywords provided by National Taiwan University Hospital:
primary spontaneous pneumothorax
clinical trial
Additional relevant MeSH terms:
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Pleural Diseases
Respiratory Tract Diseases
Anti-Bacterial Agents
Anti-Infective Agents