Relationship Between Topiramate Use and Ocular Angle Status

The recruitment status of this study is unknown because the information has not been verified recently.
Verified October 2007 by Chinese University of Hong Kong.
Recruitment status was  Active, not recruiting
Hong Kong Eye Hospital
Information provided by:
Chinese University of Hong Kong Identifier:
First received: September 8, 2005
Last updated: October 30, 2007
Last verified: October 2007
We test the hypothesis whether topiramate narrows the angles which may render Asians more likely to suffer from acute angle closure glaucoma.

Condition Intervention Phase
Glaucoma, Angle-Closure
Drug: Topiramate
Phase 4

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Safety Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Relationship Between Topiramate Use and Ocular Angle Status: A Prospective Pilot Study

Resource links provided by NLM:

Further study details as provided by Chinese University of Hong Kong:

Primary Outcome Measures:
  • Change(s) in ophthalmic parameters measured at baseline and after 4 weeks of treatment, including: [ Time Frame: 4 weeks ]
  • best-corrected visual acuity, refraction, Goldmann applanation tonometry, Gonioscopy, dilated fundus examination, [ Time Frame: 4 weeks ]
  • and ultrasound biomicroscopy of angle and anterior segment. [ Time Frame: 4 weeks ]

Estimated Enrollment: 15
Study Start Date: September 2004
Estimated Study Completion Date: July 2007
Detailed Description:
Topiramate is approved for the treatment of epilepsy and prophylaxis of migraine attacks. There were case reports of acute angle closure glaucoma (AACG) associated with its use. AACG is particularly common in Asians because of a higher prevalence of narrow angle., we test the hypothesis whether topiramate narrows the angles which may render them more likely to suffer from AACG.

Ages Eligible for Study:   18 Years to 75 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Participants aged 18-75 with an indication for starting topiramate.

Exclusion Criteria:

  • Patients with known allergy or intolerance to topiramate.
  • Recent exposure to topiramate (<3 months).
  • Moderate to severe renal failure.
  • Known history of renal calculi or hepatic failure
  • Inability to give informed consent.
  • Pregnant women or women of child-bearing age who do not practise an acceptable means of contraception.
  • Patients known to have angle-closure glaucoma.
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Please refer to this study by its identifier: NCT00153699

Hong Kong
Hong Kong Eye Hospital
Kowloon, Hong Kong
Prince of Wales Hospital
Shatin, Hong Kong
Sponsors and Collaborators
Chinese University of Hong Kong
Hong Kong Eye Hospital
Principal Investigator: Dexter YL Leung, MRCS Hong Kong Eye Hospital
Principal Investigator: Howan Leung, MRCP Chinese University of Hong Kong
  More Information Identifier: NCT00153699     History of Changes
Obsolete Identifiers: NCT00518063
Other Study ID Numbers: CRE-2004.310 
Study First Received: September 8, 2005
Last Updated: October 30, 2007
Health Authority: Hong Kong: Joint CUHK-NTEC Clinical Research Ethics Committee

Keywords provided by Chinese University of Hong Kong:
Side effects

Additional relevant MeSH terms:
Glaucoma, Angle-Closure
Eye Diseases
Ocular Hypertension
Anti-Obesity Agents
Neuroprotective Agents
Physiological Effects of Drugs
Protective Agents processed this record on May 26, 2016