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Prevalence of Proteinuria and Chronic Kidney Disease in Pediatric HIV-Infected Patients

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00153621
Recruitment Status : Completed
First Posted : September 12, 2005
Last Update Posted : May 5, 2008
Information provided by:
Children's Research Institute

Brief Summary:
Among adults with Human Immunodeficiency Virus (HIV) and Acquired Immunodeficiency Syndrome (AIDS), Chronic Kidney Disease (CKD) has previously been reported to occur in approximately 10% of children with HIV-infection. The frequency of CKD, its causes, and its natural history in children and adolescents with HIV-infection have not been systematically studied, particularly in the era of new anti-retroviral medications. The primary aim of this study is to determine the how common pediatric HIV-infected individuals have evidence of persistent proteinuria and CKD.

Condition or disease
Chronic Kidney Failure AIDS-Associated Nephropathy HIV Infections

  Show Detailed Description

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Study Type : Observational
Estimated Enrollment : 320 participants
Time Perspective: Prospective
Official Title: Prevalence of Proteinuria and Chronic Kidney Disease in Pediatric Patients in the Special Immunology, Burgess, and Nephrology Clinics
Study Start Date : September 2004
Actual Study Completion Date : September 2007

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Information from the National Library of Medicine

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Ages Eligible for Study:   1 Year to 21 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Known/confirmed HIV-infection or AIDS
  • Age > 1 but < 21 years of age
  • Able to tolerate discontinuation of ACEI or ARB
  • Either gender

Exclusion Criteria:

  • HIV negative status
  • Age < 1 or > 21 years of age
  • Unable to tolerate discontinuation of ACEI or ARB

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00153621

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United States, District of Columbia
Children's National Medical Center
Washington, District of Columbia, United States, 20010
Sponsors and Collaborators
Children's Research Institute
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Principal Investigator: Kevin D. McBryde, MD Children's Research Institute
Study Director: Susan L. Furth, MD, PhD Johns Hopkins University

Layout table for additonal information Identifier: NCT00153621     History of Changes
Other Study ID Numbers: 3406
NCRR 1K12RR017613-01
First Posted: September 12, 2005    Key Record Dates
Last Update Posted: May 5, 2008
Last Verified: September 2005

Keywords provided by Children's Research Institute:
Chronic Kidney Failure
Acquired Immunodeficiency Syndrome
AIDS-Associated Nephropathy

Additional relevant MeSH terms:
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HIV Infections
Immunologic Deficiency Syndromes
Kidney Diseases
Renal Insufficiency, Chronic
Renal Insufficiency
Kidney Failure, Chronic
AIDS-Associated Nephropathy
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immune System Diseases
Urologic Diseases
Urination Disorders
Urological Manifestations
Signs and Symptoms