Mechanisms of Human Cutaneous Microcirculation in Healthy Volunteers
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Microvascular dysfunctions are critical events in several diseases including diabetes. This study will develop a methodology for microvascular investigation in human skin. The purpose of the study is to investigate the physiological response of the cutaneous microcirculation to physical, thermal, mechanical or chemical stimulations.
Condition or disease
Device: pressure strain system, iontophoresisDrug: scopolaminDrug: emlaDrug: capsaicinDrug: aspirinDrug: clopidogrelDrug: celecoxibDrug: indomethacinDrug: acetylcholineDrug: sodium nitroprussideDrug: brethylliumDevice: general and local heating
This study has investigated various aspects of the physiology of the microcirculation in the past years and is still recruiting under parallel protocols of physiological investigations of the neurovascular control of the cutaneous microcirculation.
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Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Healthy volunteers with no clinical signs of, or risk factors for, vascular disease