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Mechanisms of Human Cutaneous Microcirculation in Healthy Volunteers

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified March 2007 by University Hospital, Angers.
Recruitment status was:  Recruiting
ClinicalTrials.gov Identifier:
First Posted: September 9, 2005
Last Update Posted: March 19, 2007
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
University Hospital, Angers
Microvascular dysfunctions are critical events in several diseases including diabetes. This study will develop a methodology for microvascular investigation in human skin. The purpose of the study is to investigate the physiological response of the cutaneous microcirculation to physical, thermal, mechanical or chemical stimulations.

Condition Intervention Phase
Healthy Volunteers Device: pressure strain system, iontophoresis Drug: scopolamin Drug: emla Drug: capsaicin Drug: aspirin Drug: clopidogrel Drug: celecoxib Drug: indomethacin Drug: acetylcholine Drug: sodium nitroprusside Drug: brethyllium Device: general and local heating Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Primary Purpose: Diagnostic
Official Title: Etude de la Reserve Vasomotrice Microcirculatoire cutanée

Further study details as provided by University Hospital, Angers:

Primary Outcome Measures:
  • Amplitude of the vasomotor response to stimuli

Secondary Outcome Measures:
  • Kinetics of the vasomotor response to stimuli

Estimated Enrollment: 85
Study Start Date: January 1996
Estimated Study Completion Date: January 2008
Detailed Description:
This study has investigated various aspects of the physiology of the microcirculation in the past years and is still recruiting under parallel protocols of physiological investigations of the neurovascular control of the cutaneous microcirculation.

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Healthy volunteers with no clinical signs of, or risk factors for, vascular disease

Exclusion Criteria:

  • Smokers, Pregnancy, Allergy,
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00152724

Contact: Pierre ABRAHAM, MD, PhD (0)2-41-35-46-17 ext 33 piabraham@chu-angers.fr

Laboratoire de Physiologie et Explorations Vasculaires - CHU Angers Recruiting
Angers, France, 49033
Contact: Pierre ABRAHAM, MD, PhD    (0)2-41-35-46-17 ext 33    piabraham@chu-angers.fr   
Sponsors and Collaborators
University Hospital, Angers
Principal Investigator: Jean Louis SAUMET, MD - PhD University Hospital, Angers
  More Information


ClinicalTrials.gov Identifier: NCT00152724     History of Changes
Other Study ID Numbers: CP96-04
First Submitted: September 8, 2005
First Posted: September 9, 2005
Last Update Posted: March 19, 2007
Last Verified: March 2007

Keywords provided by University Hospital, Angers:
Laser-Doppler Flowmetry

Additional relevant MeSH terms:
Platelet Aggregation Inhibitors
Purinergic P2Y Receptor Antagonists
Purinergic P2 Receptor Antagonists
Purinergic Antagonists
Purinergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs
Cyclooxygenase 2 Inhibitors
Cyclooxygenase Inhibitors
Enzyme Inhibitors
Anti-Inflammatory Agents, Non-Steroidal
Analgesics, Non-Narcotic
Sensory System Agents
Peripheral Nervous System Agents
Anti-Inflammatory Agents
Antirheumatic Agents
Dermatologic Agents
Gout Suppressants
Tocolytic Agents
Reproductive Control Agents
Vasodilator Agents