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Impact of nCPAP Treatment on Liver Function in Patients With Sleep Apnea Syndrome and Nonalcoholic Steatohepatitis

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified September 2005 by University Hospital, Angers.
Recruitment status was:  Recruiting
Information provided by:
University Hospital, Angers Identifier:
First received: September 8, 2005
Last updated: February 12, 2007
Last verified: September 2005
This study aims to evaluate the impact of nasal continuous positive airway pressure (nCPAP) treatment on liver enzymes in patients with sleep apnea syndrome and nonalcoholic steatohepatitis. Using a cross over design, the evolution of liver enzymes will be evaluated in 40 patients during a consecutive period of 6 weeks, with and without nCPAP treatment.

Condition Intervention
Sleep Apnea Syndrome
Nonalcoholic Steatohepatitis
Device: nCPAP

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Impact of nCPAP Treatment on Liver Function in Patients With Sleep Apnea Syndrome and Nonalcoholic Steatohepatitis: A Prospective Cross Over Trial

Resource links provided by NLM:

Further study details as provided by University Hospital, Angers:

Estimated Enrollment: 40
Study Start Date: September 2004

Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • 18 to 70 years old
  • Nonalcoholic steatohepatitis proven by liver biopsy
  • Sleep apnea syndrome proven by polysomnography with an apnea-hypopnea index > 10 events/hour
  • Informed consent

Exclusion Criteria:

  • Psychiatric disorder
  • Other cause of liver disease
  • Professional driver
  Contacts and Locations
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Please refer to this study by its identifier: NCT00152711

Contact: Frédéric Gagnadoux, MD 33(0)241353695

University Hospital Angers Recruiting
Angers, France
Contact: Frédéric Gagnadoux, MD    33(0)241353695   
Sponsors and Collaborators
University Hospital, Angers
Principal Investigator: Frédéric Gagnadoux UH Angers
  More Information Identifier: NCT00152711     History of Changes
Other Study ID Numbers: PHRC 03-07
Study First Received: September 8, 2005
Last Updated: February 12, 2007

Additional relevant MeSH terms:
Sleep Apnea Syndromes
Fatty Liver
Non-alcoholic Fatty Liver Disease
Pathologic Processes
Respiration Disorders
Respiratory Tract Diseases
Signs and Symptoms, Respiratory
Signs and Symptoms
Sleep Disorders, Intrinsic
Sleep Wake Disorders
Nervous System Diseases
Liver Diseases
Digestive System Diseases processed this record on April 28, 2017