Dexamethasone Versus Methylprednisolone for the Treatment of Active Inflammatory Bowel Disease
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Layout table for eligibility information
Ages Eligible for Study:
6 Years to 19 Years (Child, Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Parental informed consent
Subjects 6 to 19 years of age with confirmed diagnosis of IBD (Crohn's disease, ulcerative colitis or indeterminate colitis), who on admission to the hospital have a PCDAI>15 or a Clinical-Activity Index for the Evaluation of Patients with Ulcerative Colitis of >10.
Infectious causes (viruses, bacteria, parasites) have been ruled out.
Subjects in which the administration of corticosteroids would be contraindicated such as systemic or enteric infections diagnosed by stool analysis including culture, Clostridium Difficile toxin assay, rotavirus or adenovirus 40/41 antigens.
Subjects with enterostomy or colostomy
Subjects with one or more of the following conditions: unstable vital signs, acute abdomen, toxic megacolon, intestinal obstruction, intestinal perforation