Orthotopic Liver Transplantation Using a Living Donor
The purpose of this study is to:
determine the safety of donor right hepatic lobectomy as a procedure to provide a liver graft for living donor liver transplantation.
study the regeneration of liver tissue by volumetric testing for both donor and recipient.
assess if graft and patient survival with living donor transplantation is comparable to that of cadaveric donor transplantation.
Procedure: donor right hepatic lobectomy
|Study Design:||Allocation: Non-Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Orthotopic Liver Transplantation Using a Living Donor Into An Adult Recipient|
- The primary outcome for donors in this study will be the determination of whether right hepatic lobectomy is a safe procedure for the donor as measured by survival, the incidence of surgical complications, liver function and regeneration studies. [ Time Frame: post transplant ] [ Designated as safety issue: Yes ]
- The primary outcome for recipients will be the assessment of patient and graft survival. Comparison to results of contemporaneous, non-randomized cadaver donor transplants will be made. [ Time Frame: post transplant ] [ Designated as safety issue: No ]
|Study Start Date:||April 2000|
|Study Completion Date:||September 2006|
|Primary Completion Date:||September 2006 (Final data collection date for primary outcome measure)|
Please refer to this study by its ClinicalTrials.gov identifier: NCT00152607
|United States, Illinois|
|The University of Chicago Hospitals|
|Chicago, Illinois, United States, 60637|
|Principal Investigator:||J. Michael Millis, MD||The University of Chicago Hospitals|