Salt Reduction on Blood Pressure and Cardiovascular Organ Damage
Recruitment status was Recruiting
The purpose of this study is to determine the effect of a modest reduction in salt intake on blood pressure in white, black and Asian individuals with hypertension or prehypertension, and also to determine whether a modest reduction in salt intake has beneficial effects on the surrogate markers of target organ damage in cardiovascular disease.
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Primary Purpose: Treatment
|Official Title:||Effects of Modest Salt Reduction on Blood Pressure and Markers of Target Organ Damage in Patients With Untreated Essential Hypertension or Prehypertension|
- Blood pressure and markers of target organ damage at 6 weeks of usual salt intake vs those at 6 weeks of reduced salt intake.
- Comparisons among different ethnic groups in the changes in blood pressure and markers of target organ damage from week 6 of usual salt intake to week 6 of reduced salt intake.
|Study Start Date:||April 2004|
|Estimated Study Completion Date:||December 2007|
The average salt intake for adults in the UK is approximately 10-12 g/day. The current recommendations are to reduce salt intake to 5-6 g/day or less. Many randomised trials have shown that this reduction in salt intake has a significant effect on blood pressure, however, most previous trials were carried out in white individuals, fewer in blacks, and none in Asians.
Increasing evidence from epidemiological studies in humans and experimental studies in animals suggest that that our current high salt intake may have other harmful effects on cardiovascular health e.g. a direct effect on stroke, left ventricular hypertrophy, progression of renal disease and proteinuria independent of and additive to salt’s effect on blood pressure. However, no well-controlled trials have studied whether a modest reduction in salt intake has beneficial effects on the surrogate markers of target organ damage in cardiovascular disease.
We propose to carry out a double-blind randomised trial to study the effects of a modest reduction in salt intake, as currently recommended, on blood pressure and target organ damage assessed by the measurements of 24 hour urinary albumin excretion, left ventricular mass, left ventricular diastolic function, pulse wave velocity and capillary density, in white, black and Asian individuals with hypertension or prehypertension.
Comparisons: Usual salt intake compared to reduced salt intake.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00152074
|Contact: Feng J He, PhD||0044-20-8725 email@example.com|
|Contact: Graham A MacGregor, MD||0044-20-8725 firstname.lastname@example.org|
|St. George's University of London,||Recruiting|
|London, United Kingdom, SW17 0RE|
|Contact: Feng J He, PhD 0044-20-8725 5375 email@example.com|
|Contact: Graham A MacGregor, MD 0044-20-8725 5774 firstname.lastname@example.org|
|Principal Investigator: Feng J He, PhD|
|Principal Investigator: Graham A MacGregor, MD|
|Principal Investigator:||Graham A MacGregor, MD||St George's, University of London|