Effects of Daily Home Hemodialysis on Circulation, Mental Functions, and Quality of Life
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00150956|
Recruitment Status : Completed
First Posted : September 8, 2005
Last Update Posted : September 8, 2005
This study was designed to discover mechanisms responsible for the decrease in (high) blood pressure after starting daily hemodialysis, as has been observed by various investigators. We hypothesized that better control of body water and sodium content and a decline in the autonomic (sympathetic) nervous system activity, increased in chronic renal failure patients, would contribute to improved blood pressure regulation.
Moreover, we studied the effects of daily hemodialysis on mental functions, like information processing and memory, in relation to the previously reported improvement in quality of life, and the effects on nutrition. We hypothesized that all would improve.
|Condition or disease||Intervention/treatment||Phase|
|End-Stage Renal Disease||Procedure: Daily home hemodialysis||Phase 3|
Although conventional hemodialysis has faced many technical improvements in recent years, a great deal of end-stage renal disease patients, treated with this modality, have suboptimal or high blood pressure, and suffer poor quality of life. Daily hemodialysis has been reported to improve both, but the pathophysiological background is poorly understood.
Patients were studied before and after 6 months of daily (i.e.6 times a week) home hemodialysis, and again after two months of conventional (i.e. thrice weekly) hemodialysis.
We measured the effects of daily dialysis (compared with conventional dialysis) on blood pressure, cardiac output, extracellular fluid volume, plasma renin activity, sympathetic nervous system activity (through MSNA), the electroencephalogram (EEG), neurocognitive functioning (speed of information processing, memory, executive functioning, and attention), quality of life, and nutritional status
|Study Type :||Interventional (Clinical Trial)|
|Enrollment :||12 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Study Into the Effects of Daily Home Hemodialysis on Hemodynamics, Neurocognitive Functions, and Quality of Life|
|Study Start Date :||April 1999|
|Study Completion Date :||January 2002|
- Blood pressure at 6 months
- Cardiac output at 6 months
- Extracellular fluid volume at 6 months
- Plasma renin activity at 6 months
- Muscle sympathetic nerve activity (MSNA) at 6 months
- Electroencephalogram (EEG) at 6 months
- Neurocognitive functioning at 6 months
- Quality of life at 6 months
- Nutritional status at 6 months
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00150956
|UMC Utrecht, Department of Nephrology & Hypertension|
|Utrecht, Netherlands, 3584 CX|
|Principal Investigator:||Pieter F Vos, MD||UMC Utrecht, Department of Nephrology & Hypertension|