Effects of Sublingual Immunotherapy on Grasspollen Allergy
The objective of the study is to document the objective immunological effects of SLIT on the nasal mucosa. Better understanding of these immunological pathways, in which this widely practised clinical therapy is likely to work, can only benefit the overall outcome of this, more patient friendly, therapy and it will demonstrate the effects of SLIT on the allergic reaction, with objective parameters, in the nasal tissues showing it to be a true etiological treatment of allergy.
Procedure: Nasal biopsy
Procedure: Nasal washing
Procedure: Peak nasal inspiratory flow
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Primary Purpose: Treatment
|Official Title:||A Placebo Controlled, Double-Blind, Randomised Study to Assess Efficacy of Sublingual Immunotherapy in Patients With Grass Pollen Allergy Through Assessment of Its Immunological Effects on the Mucosal Tissue of the Nose.|
- Double blind placebo controlled evaluation of the immunological effects of SLIT on the nasal mucosal tissue of adult humans with sever
- I. Correlating immunological effects to a retrospective subjective complaint reduction.
- II. Rescue medication decrease through SLIT.
- III. Determining the effects of SLIT on decongestion.
- IV. Assessment of treatment compliance.
|Study Start Date:||January 2002|
|Estimated Study Completion Date:||December 2006|
Double blind placebo controlled evaluation of the immunological effects (decrease of IgE specific cells and the decrease of Th2 mediator release, respectively increase of Th1 mediator release) of SLIT on the nasal mucosal tissue of adult humans with severe rhinocunjunctivitis due to grass pollen allergy.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00150514
|Radboud university hospital|
|Nijmegen, Gelderland, Netherlands, 6500|
|Study Chair:||K Ingels, MD||Radboud University|