Randomized Controlled Trial to Evaluate Surgical Approaches to Gastric Cancer Invading the Esophagus (JCOG9502)
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.
Read our disclaimer for details.
To compare left thoraco-abdominal approach with abdominal and transhiatal approach to cardia or subcardia cancer
Condition or disease
Procedure: Surgery: abdominal and transhiatal approachProcedure: Surgery: left thoraco-abdominal approach
For gastric cancers with esophageal invasion (Siewert type II and III), thoraco-abdominal approach has shown better survival results than abdominal approach in retrospective analyses. However, patients having mediastinal nodal metastasis have poor prognosis and the benefit of thoraco-abdominal approach is still controversial. We evaluated the two approaches in a prospective randomized trial.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study:
up to 75 Years (Child, Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
histologically proven adenocarcinoma
75 years old or younger
forced expiratory volume in one second ≥ 50 %
arterial oxygen pressure in room air ≥ 70 mmHg
clinically T2/T3/T4 with ≤3 cm esophageal invasion
Carcinoma in the remnant stomach
Borrmann type 4 (linitis plastica)
synchronous or metachronous malignancy in other organs except for cervical carcinoma in situ and colorectal focal cancer in adenoma
history of left thoracotomy, or left pleural adhesion
past history of myocardial infarction or positive results of exercise ECG
liver cirrhosis, or chronic liver disease with indocyanine green test ≥15%