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Activity of the Auditory Cortex During Speech Perception and Speech Production in Stuttering

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified September 2006 by University Hospital Muenster.
Recruitment status was:  Recruiting
Information provided by:
University Hospital Muenster Identifier:
First received: September 6, 2005
Last updated: April 26, 2007
Last verified: September 2006

The goal of the study is to examine the cortical activity during speech perception and speech production in idiopathic stutterers compared to fluent speakers. Therefore, the noninvasive method of magnetoencephalography (MEG) is used. A better understanding for the complexity of speech perception and its pathology should be developed.

Fundamental properties of stuttering are repetitions, prolongations, and blocks. In most cases stuttering emerges between 2 and 5 years of age. The auditory feedback should become less important during development, as soon as information about mispronounced words does not occur anymore. During speech development this control function should be adopted by other systems. In stutterers the dominance of the acoustic control should remain.

Brain imaging studies with positron emission tomography (PET) or magnetic resonance imaging (MRI) show defects in the network of motor system, in the lateralization of speech areas, and functions of the auditory cortex. Magnetoencephalographic studies describe a similar variety as cause of stuttering. There may be defects in the auditory feedback, a modification of the lateralization of speech areas, or an alteration of co-action of motor planning and auditory system.

The benefit of magnetoencephalography is a very good temporal resolution in the range of milliseconds combined with good spatial resolution. Therefore, it is well suited to examine the dynamics of cortical processing during stuttering. In this study evoked components of the auditory systems related to complex sounds, vocals, consonant-vocal combinations, and single words are analyzed. Differences of these components in the auditory cortices of stutterers and fluent speakers are hypothesized as well in temporal structure as in localization and lateralization.


Study Type: Observational
Study Design: Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Cross-Sectional
Time Perspective: Prospective
Official Title: Evoked and Induced Auditory Cortical Activity During Speech Perception and Speech Production in Stuttering

Resource links provided by NLM:

Further study details as provided by University Hospital Muenster:

Estimated Enrollment: 20
Study Start Date: November 2004

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Subjects with idiopathic stuttering (for the group of stutterers)
  • Fluently speaking subjects (for the control group)
  • Right handed
  • Normal hearing

Exclusion Criteria:

  • Neurological diseases
  • Psychiatric diseases
  • Medication with neurological effective drugs
  • Implants with magnetic impact
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00148161

Contact: Antoinette G Dinnesen, Prof. Dr. +49(0)251 83 ext 56859
Contact: Arne Knief, Dr. +49(0)251 83 ext 56886

Institute for Biomagnetism and Biosignalanalysis Recruiting
Münster, Germany, 48149
Contact: Christo Pantev, Prof. Dr.    +49(0)251 83 ext 56865   
Principal Investigator: Christo Pantev, Prof. Dr.         
Department of Phoniatrics and Pediatric Audiology, University Hospital Münster Recruiting
Münster, Germany, 48161
Contact: Antoinette G Dinnesen, Prof. Dr.    +49(0)251 83 ext 56859   
Principal Investigator: Antoinette G Dinnesen, Prof. Dr.         
Principal Investigator: Arne Knief, Dr.         
Sub-Investigator: Michael Schneider         
Sponsors and Collaborators
University Hospital Muenster
Study Director: Antoinette G Dinnesen, Prof. Dr. Department of Phoniatrics and Pediatric Audiology, University Hospital Münster
Principal Investigator: Arne Knief, Dr. Department of Phoniatrics and Pediatric Audiology, University Hospital Münster
  More Information

Additional Information: Identifier: NCT00148161     History of Changes
Other Study ID Numbers: phonpaed001
Study First Received: September 6, 2005
Last Updated: April 26, 2007

Keywords provided by University Hospital Muenster:
Auditory cortex
Non stuttering

Additional relevant MeSH terms:
Speech Disorders
Language Disorders
Communication Disorders
Neurobehavioral Manifestations
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms processed this record on May 24, 2017