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Activity of the Auditory Cortex During Speech Perception and Speech Production in Stuttering

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ClinicalTrials.gov Identifier: NCT00148161
Recruitment Status : Unknown
Verified September 2006 by University Hospital Muenster.
Recruitment status was:  Recruiting
First Posted : September 7, 2005
Last Update Posted : April 27, 2007
Sponsor:
Information provided by:
University Hospital Muenster

Brief Summary:

The goal of the study is to examine the cortical activity during speech perception and speech production in idiopathic stutterers compared to fluent speakers. Therefore, the noninvasive method of magnetoencephalography (MEG) is used. A better understanding for the complexity of speech perception and its pathology should be developed.

Fundamental properties of stuttering are repetitions, prolongations, and blocks. In most cases stuttering emerges between 2 and 5 years of age. The auditory feedback should become less important during development, as soon as information about mispronounced words does not occur anymore. During speech development this control function should be adopted by other systems. In stutterers the dominance of the acoustic control should remain.

Brain imaging studies with positron emission tomography (PET) or magnetic resonance imaging (MRI) show defects in the network of motor system, in the lateralization of speech areas, and functions of the auditory cortex. Magnetoencephalographic studies describe a similar variety as cause of stuttering. There may be defects in the auditory feedback, a modification of the lateralization of speech areas, or an alteration of co-action of motor planning and auditory system.

The benefit of magnetoencephalography is a very good temporal resolution in the range of milliseconds combined with good spatial resolution. Therefore, it is well suited to examine the dynamics of cortical processing during stuttering. In this study evoked components of the auditory systems related to complex sounds, vocals, consonant-vocal combinations, and single words are analyzed. Differences of these components in the auditory cortices of stutterers and fluent speakers are hypothesized as well in temporal structure as in localization and lateralization.


Condition or disease
Stuttering

Study Type : Observational
Estimated Enrollment : 20 participants
Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Cross-Sectional
Time Perspective: Prospective
Official Title: Evoked and Induced Auditory Cortical Activity During Speech Perception and Speech Production in Stuttering
Study Start Date : November 2004

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Stuttering





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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Subjects with idiopathic stuttering (for the group of stutterers)
  • Fluently speaking subjects (for the control group)
  • Right handed
  • Normal hearing

Exclusion Criteria:

  • Neurological diseases
  • Psychiatric diseases
  • Medication with neurological effective drugs
  • Implants with magnetic impact

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00148161


Contacts
Contact: Antoinette G Dinnesen, Prof. Dr. +49(0)251 83 ext 56859 a.g.dinnesen@uni-muenster.de
Contact: Arne Knief, Dr. +49(0)251 83 ext 56886 knief@uni-muenster.de

Locations
Germany
Institute for Biomagnetism and Biosignalanalysis Recruiting
Münster, Germany, 48149
Contact: Christo Pantev, Prof. Dr.    +49(0)251 83 ext 56865    pantev@uni-muenster.de   
Principal Investigator: Christo Pantev, Prof. Dr.         
Department of Phoniatrics and Pediatric Audiology, University Hospital Münster Recruiting
Münster, Germany, 48161
Contact: Antoinette G Dinnesen, Prof. Dr.    +49(0)251 83 ext 56859    a.g.dinnesen@uni-muenster.de   
Principal Investigator: Antoinette G Dinnesen, Prof. Dr.         
Principal Investigator: Arne Knief, Dr.         
Sub-Investigator: Michael Schneider         
Sponsors and Collaborators
University Hospital Muenster
Investigators
Study Director: Antoinette G Dinnesen, Prof. Dr. Department of Phoniatrics and Pediatric Audiology, University Hospital Münster
Principal Investigator: Arne Knief, Dr. Department of Phoniatrics and Pediatric Audiology, University Hospital Münster

Additional Information:
ClinicalTrials.gov Identifier: NCT00148161     History of Changes
Other Study ID Numbers: phonpaed001
First Posted: September 7, 2005    Key Record Dates
Last Update Posted: April 27, 2007
Last Verified: September 2006

Keywords provided by University Hospital Muenster:
Magnetoencephalography
Auditory cortex
Stuttering
Non stuttering

Additional relevant MeSH terms:
Stuttering
Speech Disorders
Language Disorders
Communication Disorders
Neurobehavioral Manifestations
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms