Changes in Nasal Patency With Changes in Posture, Temperature, Humidity and Nasal Patency Seen by Acoustic Rhinometry
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|ClinicalTrials.gov Identifier: NCT00147888|
Recruitment Status : Completed
First Posted : September 7, 2005
Last Update Posted : September 5, 2013
|Condition or disease||Intervention/treatment||Phase|
|Mucosal Congestion||Procedure: Acoustic rhinometry (procedure)||Phase 4|
The purpose of this study was to utilize acoustic rhinometry to assess changes in nasal patency after alterations in posture, unilateral mechanical obstruction, temperature, and humidity.
Eight healthy adult volunteer subjects underwent acoustic rhinometry under the following conditions: 1) upright, sitting position (control), 2) supine position, 3) left lateral recumbent position, 4) one nostril mechanically blocked, 5) icepack on neck, 6) drinking cold water, 7) drinking hot water, 8) nasal nebulizer, 9)oxymetazoline decongestant.
Changes in nasal cavity volumes were detected by acoustic rhinometry after alterations in posture, unilateral mechanical obstruction, temperature, and humidity. Nebulizer treatment and hot water ingestion caused a significant decrease in nasal volume. The nose was able to adapt to environmental and physiological changes in order to maintain a consistent total nasal volume.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||15 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Physiological Changes in Nasal Patency in Response to Changes in Posture, Temperature, Humidity and Nasal Patency Measured by Acoustic Rhinometry|
|Study Start Date :||March 2004|
|Actual Primary Completion Date :||December 2006|
|Actual Study Completion Date :||December 2006|
Procedure: Acoustic rhinometry (procedure)
- Changes in nasal patency [ Time Frame: 5-10 minutes ]
- Nasal volume [ Time Frame: 5-10 minutes ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00147888
|United States, Illinois|
|The University of Chicago|
|Chicago, Illinois, United States, 60637|
|Principal Investigator:||Jacquelynne P. Corey, M.D.||University of Chicago|