Effect of Sarpogrelate on Platelet Aggregation in Patients With Cerebral Infarction: Dose-responsive Clinical Pharmacology Study
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|ClinicalTrials.gov Identifier: NCT00147303|
Recruitment Status : Completed
First Posted : September 7, 2005
Last Update Posted : April 10, 2015
Sarpogrelate is an antiplatelet agent that decreases 5-hydroxytryptamine( 5-HT )levels in platelets via blockade of 5-HT2 receptors, has been used in atherosclerotic peripheral arterial disease.
The present double-blind controlled clinical pharmacology study was performed on 45 patients with cerebral infarction, who were given 75, 150, or 300 mg three times daily of sarpogrelate for 7 days in order to evaluate the dose-response relationship in terms of the precisely measured inhibition of platelet aggregation.
|Condition or disease||Intervention/treatment||Phase|
|Cerebral Infarction||Drug: MCI-9042||Phase 3|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||46 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|
|Official Title:||Effect of Sarpogrelate on Platelet Aggregation in Patients With Cerebral Infarction: Clinical-pharmacological Dose-response Study.|
|Study Start Date :||April 2004|
|Actual Primary Completion Date :||January 2005|
|Actual Study Completion Date :||January 2005|
Experimental: group L
Experimental: group M
Experimental: group H
- The maximum intensity of platelet aggregation on the last day of medication and as post-treatment percentage inhibition of the maximum intensity of platelet aggregation at baseline [(baseline - post-treatment )/baseline × 100 in each subject].
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00147303
|Study Chair:||Shinichiro Uchiyama, MD||Tokyo Women's Medical University|