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Comparison of Three Different Strategies to Prevent Propofol Induced Pain During Infusion

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified April 2007 by Hospices Civils de Lyon.
Recruitment status was:  Active, not recruiting
Information provided by:
Hospices Civils de Lyon Identifier:
First received: September 5, 2005
Last updated: April 26, 2007
Last verified: April 2007
Propofol is a popular intravenous drug to induce anesthesia but it causes local pain with an incidence between 40 and 90%. Three different strategies to prevent propofol induced pain will be studied compared with placebo. Pain will be scored with a four-point scale.

Condition Intervention Phase
Induction of Total Intravenous General Anesthesia Drug: kétamine 20mg Drug: ephedrine 3mg Drug: lidocaine 40mg Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Official Title: Comparison of Three Different Strategies to Prevent Propofol Induced Pain During Infusion

Resource links provided by NLM:

Further study details as provided by Hospices Civils de Lyon:

Primary Outcome Measures:
  • After prophylactic solution, evaluation of the pain caused by injection of propofol with a four-point scale before lose of consciousness

Secondary Outcome Measures:
  • Explicite and implicite memory of pain immediately after surgery and on day one
  • Adverse effects

Estimated Enrollment: 200
Study Start Date: September 2005

Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

Healthy adults (ASA 1-2) for scheduled surgery under general anesthesia with propofol

Exclusion Criteria:

  • pregnant
  • sedative or analgesic drug 24h before surgery
  • allergy with drug used in the study
  • difficulty of communication
  • absence of informed written consent
  Contacts and Locations
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Please refer to this study by its identifier: NCT00146926

Grégoire CHATAIN
Lyon, France, 69495
Sponsors and Collaborators
Hospices Civils de Lyon
Principal Investigator: Vincent PIRIOU, MD Hospices Civils de Lyon
  More Information Identifier: NCT00146926     History of Changes
Other Study ID Numbers: 2004.367
Study First Received: September 5, 2005
Last Updated: April 26, 2007

Keywords provided by Hospices Civils de Lyon:
general anesthesia

Additional relevant MeSH terms:
Anesthetics, Local
Central Nervous System Depressants
Physiological Effects of Drugs
Sensory System Agents
Peripheral Nervous System Agents
Anti-Arrhythmia Agents
Voltage-Gated Sodium Channel Blockers
Sodium Channel Blockers
Membrane Transport Modulators
Molecular Mechanisms of Pharmacological Action
Hypnotics and Sedatives
Anesthetics, Intravenous
Anesthetics, General
Anesthetics, Dissociative
Excitatory Amino Acid Antagonists
Excitatory Amino Acid Agents
Neurotransmitter Agents
Central Nervous System Stimulants
Autonomic Agents
Vasoconstrictor Agents
Adrenergic Agents processed this record on September 21, 2017