Immunoadsorption of LPS, C5a and IL-6 in Severe Sepsis and Septic Shock (ISASS-1)
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The purpose of this study is to determine whether immunoadsorption of LPS, Il-6 and C5a reduces systemic hyperinflammation, improves immune function and improves organ function in patients with severe sepsis and septic shock
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Ages Eligible for Study:
18 Years to 80 Years (Adult, Older Adult)
Sexes Eligible for Study:
Diagnosis of severe sepsis or septic shock (ACCP/SCCM)
Presence of 4 SIRS criteria/indicators
Suspected or proven infection (refer also to: 1.)
APACHE II score > 18
At least one acute organ dysfunction (renal/pulmonary/hemodynamics/cerebral)
Suspected or proven pregnancy
Absolute contraindication for anticoagulation (active bleeding)
History of anaphylactic reaction to egg-albumin
Participants in other clinical trials (<12 wks. prior to study inclusion)