Try our beta test site
IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more...

Cognitive Training in the Elderly

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified September 2005 by Beersheva Mental Health Center.
Recruitment status was:  Recruiting
Information provided by:
Beersheva Mental Health Center Identifier:
First received: September 4, 2005
Last updated: September 5, 2010
Last verified: September 2005


The aging of the population has lead to a significant increase in the number of older people suffering from cognitive impairment and dementia. The present lack of effective drug therapy for these conditions makes it imperative to investigate other potential therapeutic interventions.

Cognitive training has been described as possibly useful in improving cognitive function in elderly subjects with mild impairment and early dementia. However, there have been few well-designed studies to date and the results are equivocal. Most studies have relied on the use of paper-based neuropsychological assessment instruments with limited accuracy and reproducibility. The investigators have developed a validated computerized neuropsychological assessment battery with increased test-retest reliability.

The purpose of this study is to assess the efficacy of a computerized training program on cognitive function in older persons with normal cognition, mild cognitive impairment, and early dementia.


A randomized prospective AB/BA crossover study.


Eligible males and females aged 60 years and older following initial computerized neuropsychological assessment will be randomized to receive either a 12-session computerized cognitive training program, or no treatment. Repeat neuropsychological assessment will be followed by a 4-week no treatment phase, reassessment and crossover phase. Repeat assessments will be performed at three and six months.

Condition Intervention
Behavioral: computerized cognitive training

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: The Effect of Computerized Cognitive Training on Neuropsychological Measures of Cognitive Function in the Elderly

Resource links provided by NLM:

Further study details as provided by Beersheva Mental Health Center:

Primary Outcome Measures:
  • changes in cognitive function

Estimated Enrollment: 300
Study Start Date: September 2005
Estimated Study Completion Date: June 2007

Ages Eligible for Study:   60 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Age: above 60 years old

Exclusion Criteria:

  • Visual impairment
  • Educational inability to perform training
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00146263

Contact: Tzvi Dwolatzky, MD 972-8-6401416
Contact: Yaacov Grinshpun, MD 972-8-6401520

Beersheva Mental Health Center Recruiting
Beersheva, Israel
Contact: Tzvi Dwolatzky, MD    972-8-6401416   
Principal Investigator: Tzvi Dwolatzky, MD         
Sponsors and Collaborators
Beersheva Mental Health Center
Principal Investigator: Tzvi Dwolatzky, MD Ben-Gurion University of the Negev
  More Information Identifier: NCT00146263     History of Changes
Other Study ID Numbers: BMHC-4018CTIL
Study First Received: September 4, 2005
Last Updated: September 5, 2010

Keywords provided by Beersheva Mental Health Center:
mild cognitive impairment
Alzheimer's Disease
cognitive training

Additional relevant MeSH terms:
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Neurocognitive Disorders
Mental Disorders processed this record on April 28, 2017