Cognitive Training in the Elderly
|ClinicalTrials.gov Identifier: NCT00146263|
Recruitment Status : Unknown
Verified September 2005 by Beersheva Mental Health Center.
Recruitment status was: Recruiting
First Posted : September 7, 2005
Last Update Posted : September 8, 2010
The aging of the population has lead to a significant increase in the number of older people suffering from cognitive impairment and dementia. The present lack of effective drug therapy for these conditions makes it imperative to investigate other potential therapeutic interventions.
Cognitive training has been described as possibly useful in improving cognitive function in elderly subjects with mild impairment and early dementia. However, there have been few well-designed studies to date and the results are equivocal. Most studies have relied on the use of paper-based neuropsychological assessment instruments with limited accuracy and reproducibility. The investigators have developed a validated computerized neuropsychological assessment battery with increased test-retest reliability.
The purpose of this study is to assess the efficacy of a computerized training program on cognitive function in older persons with normal cognition, mild cognitive impairment, and early dementia.
A randomized prospective AB/BA crossover study.
Eligible males and females aged 60 years and older following initial computerized neuropsychological assessment will be randomized to receive either a 12-session computerized cognitive training program, or no treatment. Repeat neuropsychological assessment will be followed by a 4-week no treatment phase, reassessment and crossover phase. Repeat assessments will be performed at three and six months.
|Condition or disease||Intervention/treatment||Phase|
|Dementia||Behavioral: computerized cognitive training||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||300 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||None (Open Label)|
|Official Title:||The Effect of Computerized Cognitive Training on Neuropsychological Measures of Cognitive Function in the Elderly|
|Study Start Date :||September 2005|
|Study Completion Date :||June 2007|
- changes in cognitive function
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00146263
|Contact: Tzvi Dwolatzky, MDfirstname.lastname@example.org|
|Contact: Yaacov Grinshpun, MDemail@example.com|
|Beersheva Mental Health Center||Recruiting|
|Contact: Tzvi Dwolatzky, MD 972-8-6401416 firstname.lastname@example.org|
|Principal Investigator: Tzvi Dwolatzky, MD|
|Principal Investigator:||Tzvi Dwolatzky, MD||Ben-Gurion University of the Negev|