Weight Loss and Exercise in Physically Limited Obese Elderly Subjects

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00146133
Recruitment Status : Completed
First Posted : September 5, 2005
Last Update Posted : May 3, 2006
Information provided by:
Washington University School of Medicine

Brief Summary:
The overall purpose of this research is to determine the effect of weight loss and physical training on quality of life, physical function, metabolism, bone strength, body fat and muscle mass.

Condition or disease Intervention/treatment Phase
Obesity Frailty Elderly Behavioral: diet, exercise Phase 3

Detailed Description:
Obesity causes serious medical complications and impairs quality of life. Moreover, in elderly persons, obesity can lead to frailty because of decreased strength, joint function, balance and mobility associated with aging. The primary objective of this study is to evaluate the effect of weight loss and physical training on physical function, body composition, metabolism and quality of life in frail, obese elderly men and women. Subjects are randomized to either control or 10% weight loss plus physical training.

Study Type : Interventional  (Clinical Trial)
Enrollment : 28 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single
Primary Purpose: Treatment
Official Title: Effect of Weight Loss and Physical Training on Musculoskeletal Status, Physical Function, and Quality-of-Life in Physically Limited, Obese, Elderly Subjects
Study Start Date : January 2003
Study Completion Date : December 2004

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Primary Outcome Measures :
  1. physical function and body composition

Secondary Outcome Measures :
  1. quality of life, metabolic markers

Information from the National Library of Medicine

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Ages Eligible for Study:   65 Years to 85 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Obese (BMI 30 or greater) elderly (age 65 years or older) Frailty

Exclusion Criteria:

  • Major chronic disease or any condition that would interfere with exercise or dietary restriction, in which exercise or dietary restriction are contraindicated, or that would interfere with interpretation of results. Examples include cardiopulmonary disease, unstable disease, severe orthopedic or neuromuscular impairments, dementia, history of malignancy during the past 5 yr, current use of bone acting drugs.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00146133

United States, Missouri
Washington University School of Medicine
St Louis, Missouri, United States, 63108
Sponsors and Collaborators
Washington University School of Medicine
Principal Investigator: Dennis T Villareal, MD Washington University School of Medicine

Publications of Results:
Other Publications: Identifier: NCT00146133     History of Changes
Other Study ID Numbers: KO7AG2116401
First Posted: September 5, 2005    Key Record Dates
Last Update Posted: May 3, 2006
Last Verified: September 2005

Keywords provided by Washington University School of Medicine:
Obesity, Aging, Frailty, exercise, weight loss

Additional relevant MeSH terms:
Weight Loss
Body Weight Changes
Body Weight
Signs and Symptoms