The Role of Fluorothymidine Positron Emission Tomography (FLT-PET) in Proliferation of Colorectal Liver Metastases
|ClinicalTrials.gov Identifier: NCT00145665|
Recruitment Status : Terminated (no accrual achieved)
First Posted : September 5, 2005
Last Update Posted : September 5, 2011
The aim of the study is to obtain information on FLT used in a PET-scan as a marker for the proliferation of colorectal liver metastases, so that the risk of recurrence can be identified in a noninvasive way, concerning patients with resectable colorectal liver metastases.
The hypothesis of this study is that a higher uptake of FLT in the liver metastases has a good correlation with the proliferation rate of the metastases. This rate is related to the risk of recurrence.
|Condition or disease||Intervention/treatment||Phase|
|Colorectal Neoplasms Liver Neoplasms||Procedure: FLT-PET scan||Phase 1 Phase 2|
Aim of the Study:
Validation of FLT-PET as a proliferation marker for colorectal liver metastases, so that the risk of recurrence in patients with resected colorectal liver metastases can be assessed in a noninvasive method.
Validation study (n=40) to determine the correlation between quantitative FLT-PET (in this study determined before resection of the colorectal liver metastases) and the histologically determined proliferation index in the resected specimen of the metastases ('golden standard'). If correlation is established, the correlation between the proliferation and recurrence rate studied is also (n=80).
Patients with colorectal liver metastases.
Scientific Basis of Study:
Several reports show that presence or absence of extrahepatic disease is a determining prognostic factor. Patients with extrahepatic disease are rarely suited for resection of the liver metastases. Recently several papers describe that the proliferation index of the liver metastases is another determining prognostic factor. Patients with a high proliferation factor have a worse prognosis. For both of these determining factors, it seems that PET diagnostics play an essential role and contribute to better selection of patients suitable for resection.
Diagnostics on Proliferation:
Seeing that the proliferation rate is preoperatively not determined without a biopsy (which is contraindicated due to dissemination), all patients with colorectal liver metastases (with no signs of extrahepatic deposits) are resected, without knowledge of the proliferation. FLT is a marker that visualizes proliferation and thus seems an ideal candidate to determine the proliferation rate in a noninvasive method. As of yet no validation studies of FLT-PET in colorectal liver metastases have been described.
Quantitative histologic data are correlated with the quantitative FLT-PET data. If the correlation is higher that 0.85, this correlation is established. If this correlation is found, the inclusion of patients will be extended from 40 to 80 patients, seeing that this will give us the opportunity to correlate clinical data with the histological data. (alpha = 0.05, one-sided, beta = 0.90, assuming that an acceptable difference in sensitivity between both tests is 0 and an unacceptable difference is 0.02). If this correlation is significant, a new study will be proposed with the introduction of neoadjuvant chemotherapy, where the selection will be determined on basis of the proliferation rate.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||80 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||Double (Investigator, Outcomes Assessor)|
|Official Title:||The Role of 3-Deoxy-3Fluorothymidine Positron Emission Tomography (FLT-PET) in Proliferation of Colorectal Liver Metastases|
|Study Start Date :||January 2005|
|Estimated Primary Completion Date :||December 2011|
|Estimated Study Completion Date :||December 2012|
Procedure: FLT-PET scan
- correlation FLT-uptake in colorectal liver metastases and the histologically determined proliferation
- correlation FLT and recurrence rate
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00145665
|Nijmegen, Gelderland, Netherlands, 6500 HB|
|Principal Investigator:||Bastiaan Wiering, MD||Radboud University|
|Principal Investigator:||Theo MJ Ruers, MD, PhD||Radboud University|
|Principal Investigator:||Wim JG Oyen, MD, PhD||Radboud University|