Body Composition, Glucose Metabolism, Insulin Resistance and Gene Expression in Muscle Cells in Healthy Overweight Women
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|ClinicalTrials.gov Identifier: NCT00145392|
Recruitment Status : Completed
First Posted : September 5, 2005
Last Update Posted : June 24, 2008
In this study, we will clarify the degree of insulin resistance and characterise muscle glucose metabolism and gene expression in a group of overweight healthy women. The study will clarify how overweight influences body glucose metabolism and thereby in the long-run increases the risk for developing type 2 diabetes. Moreover, the study may clarify why some overweight women develop hormone disorders and diabetes while others remain healthy.
The study is essential as many patients suffer from diseases aggravated by overweight. In addition, a genetic disposition for diabetes or polycystic ovary syndrome may give rise to the disease if the patient gains weight. It is therefore important that weight-matched control subjects are included in projects with overweight patients.
This clinical trial includes 10 overweight women with regular hormones and normal level of male sex hormone. The patients included must be healthy, take no medications influencing the study results. The subjects must take no contraceptive pills or receive any other hormone treatment.
In connection with the investigation, the following will be carried out on all patients: clinical examination, blood tests, hyperinsulinaemic euglycaemic clamp, muscle biopsies, bone scan.
The purpose of the study is to gain more knowledge of how overweight influences women's risk of developing hormone diseases and diabetes.
|Condition or disease||Phase|
|Obesity Type 2 Diabetes Polycystic Ovary Syndrome||Phase 4|
|Study Type :||Observational|
|Estimated Enrollment :||10 participants|
|Official Title:||Body Composition, Glucose Metabolism, Insulin Resistance and Gene Expression in Muscle Cells in Healthy Overweight Women|
|Study Start Date :||September 2002|
|Primary Completion Date :||January 2007|
|Study Completion Date :||December 2007|
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00145392
|Department of Endocrinology, Odense University Hospital|
|Odense, Funen, Denmark, 5000|
|Principal Investigator:||Dorte Glintborg, MD||Odense University Hospital|