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Urokinase Versus Primary Video-Assisted Thorascopic Surgery for Empyema

This study has been completed.
Information provided by:
Institute of Child Health Identifier:
First received: September 2, 2005
Last updated: NA
Last verified: September 2005
History: No changes posted
This study will compare VATS versus chest drain insertion and urokinase in the treatment of childhood empema by a randomised prospective study.

Condition Intervention Phase
Empyema Drug: insertion of a chest drain with urokinase instillation Procedure: primary video-assisted thorascopic surgery Phase 1

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment

Resource links provided by NLM:

Further study details as provided by Institute of Child Health:

Primary Outcome Measures:
  • length of hospital stay

Secondary Outcome Measures:
  • radiological changes at follow up

Estimated Enrollment: 60

Ages Eligible for Study:   up to 16 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • patients under the age of 16 referred to GOSH for management of empyema

Exclusion Criteria:

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00144950

United Kingdom
Great Ormond Street Hospital
London, United Kingdom
Sponsors and Collaborators
Institute of Child Health
Principal Investigator: Adam Jaffe, Dr Great Ormond Street Hospital
  More Information

Publications automatically indexed to this study by Identifier (NCT Number): Identifier: NCT00144950     History of Changes
Other Study ID Numbers: 02AR04
Study First Received: September 2, 2005
Last Updated: September 2, 2005

Additional relevant MeSH terms:
Pathologic Processes processed this record on August 23, 2017