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The Effect of Isoflurane or Sevoflurane on Kidney Function

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00144118
Recruitment Status : Terminated
First Posted : September 5, 2005
Last Update Posted : September 5, 2005
Information provided by:
Austin Health

Brief Summary:
The purpose of this study is to determine if isoflurane and sevoflurane have similar effects on the kidneys of people with impaired kidneys when the drugs administered with low gas flow into anaesthetic machines.

Condition or disease Intervention/treatment Phase
Kidney Failure Drug: sevoflurane or isoflurane Phase 4

  Show Detailed Description

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Study Type : Interventional  (Clinical Trial)
Enrollment : 270 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single
Primary Purpose: Treatment
Official Title: Post-Operative Creatinine Changes In Patients With Pre-Existing Renal Impairment After Low-Flow Isoflurane Or Sevoflurane: A Randomised Clinical Trial
Study Start Date : January 2002
Study Completion Date : August 2005

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Creatinine

Primary Outcome Measures :
  1. Change in creatinine in first three postoperative days

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

Adult patients for elective surgery who will:

  • Need to stay at least one night, and
  • Need general anaesthesia, and
  • Have a pre-operative serum creatinine concentration greater than 130 umol/l.

Exclusion Criteria:

  • The patient refuses.
  • The patient is less than 18 years of age.
  • The patient is on pre-operative dialysis
  • The anaesthetist plans to use only regional or total intravenous anaesthesia.
  • Specific types of surgery: craniotomy, carotid, and cardiac.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00144118

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Australia, Victoria
Department of Anaesthesia, Austin Health
Melbourne, Victoria, Australia, 3084
Sponsors and Collaborators
Austin Health
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Principal Investigator: David A Story, MD Department of Anaesthesia, Austin Health

Layout table for additonal information Identifier: NCT00144118     History of Changes
Other Study ID Numbers: H2000/01072
First Posted: September 5, 2005    Key Record Dates
Last Update Posted: September 5, 2005
Last Verified: August 2005
Additional relevant MeSH terms:
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Renal Insufficiency
Kidney Diseases
Urologic Diseases
Platelet Aggregation Inhibitors
Anesthetics, Inhalation
Anesthetics, General
Central Nervous System Depressants
Physiological Effects of Drugs