Transitioning From Cyclosporine to Alefacept in Psoriasis
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ClinicalTrials.gov Identifier: NCT00143806
: September 2, 2005
Last Update Posted
: January 5, 2009
University of Medicine and Dentistry of New Jersey
The purpose of this study is to devise a safe and effective method for transitioning patients from cyclosporine to alefacept.
Condition or disease
Drug: Transitioning patients from cyclosporine to alefacept
The purpose of this study is to devise a safe and effective method for transitioning patients from cyclosporine to alefacept. Patients in the study are well controlled on cyclosporine and desire to switch to alefacept. The study is done in three phases. In Phase 1 (12 week duration) the two drugs will be overlapped, with cyclosporine slowly tapering. Both drugs will be discontinued after 12 weeks. In Phase 2 (12 weeks duration), patients are off both drugs. In Phase 3 (24 weeks long), patients are on a second course of alefacept alone for 12 weeks and then off for 12 weeks. Topical and UV light treatments are allowed throughout the study. Total length of study is one year.
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Ages Eligible for Study:
18 Years to 80 Years (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Adult psoriasis patients (18 to 80 years old), who are well controlled on cyclosporine (Static PGA score of mild, minimal or clear) and who need or desire to stop cyclosporine and start alefacept.
Active infection (other than trivial URI, etc.)
History of AIDS or Hepatitis B, C
Inability to understand consent or comply with study requirements