ClinicalTrials.gov
ClinicalTrials.gov Menu

Magnetic Resonance Imaging of Brain Development in Attention Deficit Hyperactivity Disorder

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT00143767
Recruitment Status : Unknown
Verified March 2007 by UMC Utrecht.
Recruitment status was:  Recruiting
First Posted : September 2, 2005
Last Update Posted : March 20, 2007
Sponsor:
Information provided by:
UMC Utrecht

Brief Summary:
The primary purpose of this study is to investigate brain whether ADHD represents a disruption or a delay of brain development. Children and adolescents both with and without ADHD are asked to participate in several MRI sessions, two years apart. This will allow us to chart brain development over time, both in typical development and ADHD, and therefore to address whether ADHD represents a disruption or a delay of typical brain development.

Condition or disease
Attention Deficit Hyperactivity Disorder

Detailed Description:

Attention Deficit Hyperactivity Disorder (ADHD) is a common and impairing neuropsychiatric disorder of childhood, occurring in 3 to 5% of all school-age children. This disorder is associated with greater risks for low academic achievement, school dropouts, poor family and peer relations, aggression, substance abuse, driving accidents and chronic problems in adult adaptation. As such, it has an enormous impact on the utilization of medical and health care services, and the direct and indirect costs of this disorder are high. However, in a large number of children symptoms dissipate as they grow up and they go on to function normally and lead typical lives. This has lead to speculation that ADHD may not so much represent a disruption, as a delay of brain development. This aim of this study is to address this issue.

There is a growing body of research supporting the existence of deficits in brain anatomy associated with ADHD, with evidence of reductions in overall brain size, cortical gray matter and subcortical structures. However, reported effect sizes are small and results not always consistent. Anatomical MRI studies may be easily confounded, as brain development is complex and associated with both progressive and regressive changes in brain anatomy. In this study, we propose to combine longitudinal data from a large cohort of children and adolescents with state-of-the-art imaging methods (including diffusion tensor imaging and voxelbased morphometry) to investigate brain development in ADHD. This will allow us to address the question whether ADHD represents a disruption or a delay of brain development.


Study Type : Observational
Enrollment : 400 participants
Observational Model: Case Control
Observational Model: Natural History
Time Perspective: Longitudinal
Time Perspective: Prospective
Official Title: Magnetic Resonance Imaging of Brain Development in Attention Deficit Hyperactivity Disorder
Study Start Date : August 2005

Resource links provided by the National Library of Medicine






Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   6 Years to 20 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Aged 6 - 18 years at initial MRI

Inclusion Criteria for Subjects with ADHD:

  • DSM-IV (APA, 1994) diagnosis of ADHD, according to DISC interview
  • Scores in the clinical range on the Child Behavior Checklist (CBCL) and Teacher Rating Form(TRF)

Inclusion Criteria for Controls:

  • No DSM-IV (APA, 1994) diagnosis, according to DISC interview
  • No scores in the clinical range on the Child Behavior Checklist (CBCL) and Teacher Rating Form (TRF)

Exclusion Criteria:

  • IQ < 70
  • Major illness of the cardiovascular, the endocrine, the pulmonal or the gastrointestinal system
  • Presence of metal objects in or around the body (pacemaker, dental braces)
  • History of or present neurological disorder
  • For individuals over 12 years of age: legal incompetence, defined as the obvious inability to comprehend the information that is presented by the investigator and is outlined in the Information letter and on which the decision to participate in the study is to be based

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00143767


Contacts
Contact: Sarah Durston, Ph.D. +31 30 250 8161 S.Durston@umcutrecht.nl

Locations
Netherlands
Dept. of Child and Adolescent Psychiatry, UMC Utrecht Recruiting
Utrecht, Netherlands
Contact: Janna van Belle, M.Sc.    +31 30 250 3275    J.vanBelle@umcutrecht.nl   
Principal Investigator: Janna van Belle, M.Sc.         
Principal Investigator: Patrick de Zeeuw, M.Sc.         
Sponsors and Collaborators
UMC Utrecht
Investigators
Principal Investigator: Sarah Durston, Ph.D. Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht
Study Chair: Herman van Engeland, M.D. Ph.D. Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht

Additional Information:
ClinicalTrials.gov Identifier: NCT00143767     History of Changes
Other Study ID Numbers: METC 05/036
First Posted: September 2, 2005    Key Record Dates
Last Update Posted: March 20, 2007
Last Verified: March 2007

Keywords provided by UMC Utrecht:
Magnetic Resonance Imaging

Additional relevant MeSH terms:
Disease
Attention Deficit Disorder with Hyperactivity
Hyperkinesis
Pathologic Processes
Attention Deficit and Disruptive Behavior Disorders
Neurodevelopmental Disorders
Mental Disorders
Dyskinesias
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms