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Amlodipine vs Nitrates Study in Patients With Chronic Stable Angina (ANISSA)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00143195
Recruitment Status : Completed
First Posted : September 2, 2005
Last Update Posted : April 18, 2007
Information provided by:

Brief Summary:
The objective of study is to compare the anti-ischemic efficacy and safety profiles of once daily amlodipine or isosorbide-5-mononitrate in the treatment of stable asymptomatic and symptomatic myocardial ischemia

Condition or disease Intervention/treatment Phase
Myocardial Ischemia Drug: Amlodipine Drug: iso- 5 - mononitrate Procedure: Blood tests Procedure: Exercise Stress Test Phase 4

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Study Type : Interventional  (Clinical Trial)
Enrollment : 200 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Open Label Study Comparing Amlodipine vs Long-Acting Nitrates in Patients With Chronic Stable Angina.
Study Start Date : April 2001
Study Completion Date : January 2005

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Angina

Primary Outcome Measures :
  1. Evaluate the time to 1mm ST depression

Secondary Outcome Measures :
  1. The number of patients experiencing angina attacks The frequency of hospitalizations due to angina attacks Time to onset of 1mm ST segment depression Total external workload performed Safety

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Outpatients > =18 years of age with diagnosed clinically stable angina pectoris

Exclusion Criteria:

  • Patients with congestive heart failure, clinically significant cardiovascular disease, standing systolic blood pressure of less than 100mmHg, concomitant anti-anginal therapies similar to sublingual NTG

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00143195

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Pfizer Investigational Site
Athens, Attika, Greece, 11527
Pfizer Investigational Site
Athens, Greece, 123 51
Pfizer Investigational Site
Athens, Greece
Pfizer Investigational Site
Holargos/Athens, Greece, 11525
Pfizer Investigational Site
Loannina, Greece, 45500
Pfizer Investigational Site
N. Ionia, Greece, 143 88
Pfizer Investigational Site
Patra, Greece, 26335
Pfizer Investigational Site
Rio, Patra, Greece, 26499
Pfizer Investigational Site
Thessaloniki, Greece, 546 36
Pfizer Investigational Site
Thessaloniki, Greece, 54639
Pfizer Investigational Site
Voula/Athens, Greece
Pfizer Investigational Site
Zakynthos, Greece, 29100
Sponsors and Collaborators
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Study Director: Pfizer Call Center Pfizer
Additional Information:
Layout table for additonal information Identifier: NCT00143195    
Other Study ID Numbers: A0531076
First Posted: September 2, 2005    Key Record Dates
Last Update Posted: April 18, 2007
Last Verified: April 2007
Additional relevant MeSH terms:
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Myocardial Ischemia
Angina, Stable
Pathologic Processes
Heart Diseases
Cardiovascular Diseases
Vascular Diseases
Angina Pectoris
Chest Pain
Neurologic Manifestations
Antihypertensive Agents
Calcium Channel Blockers
Membrane Transport Modulators
Molecular Mechanisms of Pharmacological Action
Calcium-Regulating Hormones and Agents
Physiological Effects of Drugs
Vasodilator Agents