Study to Compare the Effect of Treatment With Carbidopa/Levodopa/Entacapone on the Quality of Life of Patients With Parkinson's Disease. This Study is Not Recruiting in the United States
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This study examines the effect of treatment of levodopa/entacapone on quality of life, as measured by the Parkinson's Disease-Questionnaire 8 (PDQ-8), in Parkinson's disease patients with no or minimal, non-disabling motor fluctuations.
Condition or disease
Drug: carbidopa, levodopa, entacapone
This study examines the effect of treatment of levodopa/entacapone on quality of life, as measured by the Parkinson's Disease-Questionnaire 8 (PDQ-8), in Parkinson's disease patients with no or minimal, non-disabling motor fluctuations. Treatment with carbidopa/levodopa/entacapone will be compared with treatment with standard formulation levodopa/carbidopa.
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Ages Eligible for Study:
30 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Clinical diagnosis of idiopathic Parkinson's disease exhibiting at least 2 or 3 symptoms
Motor functions must be regarded as non-disabling by the patient
History, signs or symptoms suggesting the diagnosis of atypical or secondary parkinsonism
History of dyskinesia
Previous or current use of entacapone or tolcapone
Unstable Parkinson's disease patients requiring/receiving regimens of levodopa
Subjects taking levodopa/DDCI controlled release or extended release formulations