Time Course of Procalcitonin and C Reactive Protein in Septic Patients Under Treatment With Corticosteroids
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|ClinicalTrials.gov Identifier: NCT00141973|
Recruitment Status : Completed
First Posted : September 2, 2005
Last Update Posted : May 14, 2008
A systemic treatment with corticosteroids has been advocated for various bacterial infectious diseases. Since the production of CRP is down-regulated by corticosteroids, a smaller increase or a more rapid decrease of this acute phase protein will:
- suggest attenuated systemic inflammation, but
- does not necessarily reflect adequate therapy of the infection.
For several reasons (good diagnostic tool for sepsis, induction not decreased by immunosuppressive therapy), procalcitonin could be a better marker for activity of sepsis in patients under corticosteroids. As this issue has not yet been examined the investigators will prospectively study the time-course of PTC and CRP in a well-defined septic patient group, that in adjunction to antibiotic therapy also received systemic corticosteroid treatment and compare it to a similar group without corticosteroid treatment.
|Condition or disease|
|Study Type :||Observational|
|Study Start Date :||November 2004|
|Estimated Study Completion Date :||December 2005|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00141973
|Ospedale Regionale Bellinzona e Valli|
|Bellinzona, Ticino, Switzerland, 6500|
|Principal Investigator:||Andreas Perren, MD||Ospedale Regionale Bellinzona e Valli, CH-6500 Bellinzona|