Time Course of Procalcitonin and C Reactive Protein in Septic Patients Under Treatment With Corticosteroids

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00141973
Recruitment Status : Completed
First Posted : September 2, 2005
Last Update Posted : May 14, 2008
Brahms SA, D-16761 Hennigsdorf bei Berlin
Information provided by:
Ospedale Regionale Bellinzona e Valli

Brief Summary:

A systemic treatment with corticosteroids has been advocated for various bacterial infectious diseases. Since the production of CRP is down-regulated by corticosteroids, a smaller increase or a more rapid decrease of this acute phase protein will:

  1. suggest attenuated systemic inflammation, but
  2. does not necessarily reflect adequate therapy of the infection.

For several reasons (good diagnostic tool for sepsis, induction not decreased by immunosuppressive therapy), procalcitonin could be a better marker for activity of sepsis in patients under corticosteroids. As this issue has not yet been examined the investigators will prospectively study the time-course of PTC and CRP in a well-defined septic patient group, that in adjunction to antibiotic therapy also received systemic corticosteroid treatment and compare it to a similar group without corticosteroid treatment.

Condition or disease

Study Type : Observational
Time Perspective: Prospective
Study Start Date : November 2004
Study Completion Date : December 2005

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Sepsis
U.S. FDA Resources

Information from the National Library of Medicine

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Ages Eligible for Study:   50 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Acute exacerbation of chronic obstructive pulmonary disease (COPD) due to bacterial pneumonia

Exclusion Criteria:

  • Chronic systemic use of corticosteroids

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00141973

Ospedale Regionale Bellinzona e Valli
Bellinzona, Ticino, Switzerland, 6500
Sponsors and Collaborators
Ospedale Regionale Bellinzona e Valli
Brahms SA, D-16761 Hennigsdorf bei Berlin
Principal Investigator: Andreas Perren, MD Ospedale Regionale Bellinzona e Valli, CH-6500 Bellinzona Identifier: NCT00141973     History of Changes
Other Study ID Numbers: CE1408
First Posted: September 2, 2005    Key Record Dates
Last Update Posted: May 14, 2008
Last Verified: May 2008

Keywords provided by Ospedale Regionale Bellinzona e Valli:

Additional relevant MeSH terms:
Systemic Inflammatory Response Syndrome
Pathologic Processes
Bone Density Conservation Agents
Physiological Effects of Drugs