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Time Course of Procalcitonin and C Reactive Protein in Septic Patients Under Treatment With Corticosteroids

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00141973
First Posted: September 2, 2005
Last Update Posted: May 14, 2008
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
Brahms SA, D-16761 Hennigsdorf bei Berlin
Information provided by:
Ospedale Regionale Bellinzona e Valli
  Purpose

A systemic treatment with corticosteroids has been advocated for various bacterial infectious diseases. Since the production of CRP is down-regulated by corticosteroids, a smaller increase or a more rapid decrease of this acute phase protein will:

  1. suggest attenuated systemic inflammation, but
  2. does not necessarily reflect adequate therapy of the infection.

For several reasons (good diagnostic tool for sepsis, induction not decreased by immunosuppressive therapy), procalcitonin could be a better marker for activity of sepsis in patients under corticosteroids. As this issue has not yet been examined the investigators will prospectively study the time-course of PTC and CRP in a well-defined septic patient group, that in adjunction to antibiotic therapy also received systemic corticosteroid treatment and compare it to a similar group without corticosteroid treatment.


Condition
Sepsis

Study Type: Observational
Study Design: Time Perspective: Prospective

Resource links provided by NLM:


Further study details as provided by Ospedale Regionale Bellinzona e Valli:

Study Start Date: November 2004
Estimated Study Completion Date: December 2005
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   50 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Acute exacerbation of chronic obstructive pulmonary disease (COPD) due to bacterial pneumonia

Exclusion Criteria:

  • Chronic systemic use of corticosteroids
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00141973


Locations
Switzerland
Ospedale Regionale Bellinzona e Valli
Bellinzona, Ticino, Switzerland, 6500
Sponsors and Collaborators
Ospedale Regionale Bellinzona e Valli
Brahms SA, D-16761 Hennigsdorf bei Berlin
Investigators
Principal Investigator: Andreas Perren, MD Ospedale Regionale Bellinzona e Valli, CH-6500 Bellinzona
  More Information

ClinicalTrials.gov Identifier: NCT00141973     History of Changes
Other Study ID Numbers: CE1408
First Submitted: September 1, 2005
First Posted: September 2, 2005
Last Update Posted: May 14, 2008
Last Verified: May 2008

Keywords provided by Ospedale Regionale Bellinzona e Valli:
Procalcitonin
Sepsis
Corticosteroids

Additional relevant MeSH terms:
Sepsis
Infection
Systemic Inflammatory Response Syndrome
Inflammation
Pathologic Processes
Calcitonin
Bone Density Conservation Agents
Physiological Effects of Drugs