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Memantine in Patients With Chronic Glaucoma

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ClinicalTrials.gov Identifier: NCT00141882
Recruitment Status : Completed
First Posted : September 2, 2005
Last Update Posted : November 4, 2010
Sponsor:
Information provided by:
Allergan

Brief Summary:
Randomized double-masked clinical trial of memantine in patients with glaucoma

Condition or disease Intervention/treatment Phase
Open-Angle Glaucoma Drug: memantine Phase 3

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 1119 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Primary Purpose: Treatment
Study Start Date : March 1999
Primary Completion Date : January 2006
Study Completion Date : August 2006





Primary Outcome Measures :
  1. Progression of glaucoma


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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Glaucoma damage on examination of visual field and optic disc
  • Good visual acuity (with glasses if needed)

ClinicalTrials.gov Identifier: NCT00141882     History of Changes
Other Study ID Numbers: 192944-004
First Posted: September 2, 2005    Key Record Dates
Last Update Posted: November 4, 2010
Last Verified: November 2010

Additional relevant MeSH terms:
Glaucoma
Glaucoma, Open-Angle
Ocular Hypertension
Eye Diseases
Memantine
Antiparkinson Agents
Anti-Dyskinesia Agents
Dopamine Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs
Excitatory Amino Acid Antagonists
Excitatory Amino Acid Agents