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The Effect of Cycling Off Criteria During Pressure Support Ventilation in Chronic Obstructive Pulmonary Disease (COPD) Patients

This study has been completed.
Information provided by:
Policlinico Hospital Identifier:
First received: August 31, 2005
Last updated: December 29, 2009
Last verified: September 2008
The investigators' aim is to study the effect of cycling off criteria during pressure support ventilation in COPD patients at two levels of PEEP and PSV.

Condition Intervention
Chronic Obstructive Pulmonary Disease
Procedure: mechanical ventilation

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: The Effect of Cycling Off Criteria During Pressure Support Ventilation in Chronic Obstructive Pulmonary Disease (COPD) Patients

Resource links provided by NLM:

Further study details as provided by Policlinico Hospital:

Primary Outcome Measures:
  • Respiratory mechanics, gas exchange [ Time Frame: 2 minutes ]

Secondary Outcome Measures:
  • Comfort of breathing [ Time Frame: 2 minutes ]

Enrollment: 13
Study Start Date: July 2005
Study Completion Date: March 2007
Primary Completion Date: March 2007 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
COPD patients
Procedure: mechanical ventilation
evaluated the effect of two different cycling off criteria on breathing pattern, respiratory effort, and gas exchange in patients with chronic obstructive pulmonary disease

Detailed Description:
In this study two levels of cycling off criteria at two levels of PEEP and PSV were tested in term of gas exchange, respiratory mechanics, work of breathing and patient comfort.

Ages Eligible for Study:   16 Years to 90 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Stable COPD patients during invasive mechanical ventilation

Exclusion Criteria:

  • Hemodynamic instability,
  • Paralysis
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Please refer to this study by its identifier: NCT00141440

Ospedale Sacco
Milano, Italy, 20100
Sponsors and Collaborators
Policlinico Hospital
Principal Investigator: davide chiumello, md Policlinico Hospital
Study Chair: Davide Chiumello, MD Policlinico
  More Information

Responsible Party: Davide Chiumello, Policlinico Hospital Identifier: NCT00141440     History of Changes
Other Study ID Numbers: 1073
Study First Received: August 31, 2005
Last Updated: December 29, 2009

Keywords provided by Policlinico Hospital:
gas exchange
pressure support ventilation
respiratory mechanics
COPD patients

Additional relevant MeSH terms:
Lung Diseases
Lung Diseases, Obstructive
Pulmonary Disease, Chronic Obstructive
Respiratory Tract Diseases processed this record on May 25, 2017