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The Effect of Cycling Off Criteria During Pressure Support Ventilation in Chronic Obstructive Pulmonary Disease (COPD) Patients

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00141440
First Posted: September 1, 2005
Last Update Posted: December 30, 2009
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Policlinico Hospital
  Purpose
The investigators' aim is to study the effect of cycling off criteria during pressure support ventilation in COPD patients at two levels of PEEP and PSV.

Condition Intervention
Chronic Obstructive Pulmonary Disease Procedure: mechanical ventilation

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: The Effect of Cycling Off Criteria During Pressure Support Ventilation in Chronic Obstructive Pulmonary Disease (COPD) Patients

Resource links provided by NLM:


Further study details as provided by Policlinico Hospital:

Primary Outcome Measures:
  • Respiratory mechanics, gas exchange [ Time Frame: 2 minutes ]

Secondary Outcome Measures:
  • Comfort of breathing [ Time Frame: 2 minutes ]

Enrollment: 13
Study Start Date: July 2005
Study Completion Date: March 2007
Primary Completion Date: March 2007 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
COPD patients
Procedure: mechanical ventilation
evaluated the effect of two different cycling off criteria on breathing pattern, respiratory effort, and gas exchange in patients with chronic obstructive pulmonary disease

Detailed Description:
In this study two levels of cycling off criteria at two levels of PEEP and PSV were tested in term of gas exchange, respiratory mechanics, work of breathing and patient comfort.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   16 Years to 90 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Stable COPD patients during invasive mechanical ventilation

Exclusion Criteria:

  • Hemodynamic instability,
  • Paralysis
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00141440


Locations
Italy
Ospedale Sacco
Milano, Italy, 20100
Sponsors and Collaborators
Policlinico Hospital
Investigators
Principal Investigator: davide chiumello, md Policlinico Hospital
Study Chair: Davide Chiumello, MD Policlinico
  More Information

Publications:
Responsible Party: Davide Chiumello, Policlinico Hospital
ClinicalTrials.gov Identifier: NCT00141440     History of Changes
Other Study ID Numbers: 1073
First Submitted: August 31, 2005
First Posted: September 1, 2005
Last Update Posted: December 30, 2009
Last Verified: September 2008

Keywords provided by Policlinico Hospital:
gas exchange
pressure support ventilation
respiratory mechanics
COPD patients

Additional relevant MeSH terms:
Lung Diseases
Lung Diseases, Obstructive
Pulmonary Disease, Chronic Obstructive
Respiratory Tract Diseases