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ClinicalTrials.gov Identifier: NCT00141076
: September 1, 2005
Last Update Posted
: August 30, 2010
Boston Children’s Hospital
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
This study will compare the physiological effects of two isoenergetic, nutrient-controlled diets that differ in glycemic index. The diets will be studied in obese adults in a 10-day crossover feeding trial.
Condition or disease
Behavioral: low vs high glycemic index diet
This study will compare the physiological effects of two isoenergetic, nutrient-controlled diets that differ in glycemic index. The diets will be studied in obese male adults in a 10-day crossover feeding trial. Hypothesis: Obese subjects will show improvements in clinical endpoints associated with risk for diabetes and cardiovascular disease (CVD) after consuming a controlled low (compared to high) glycemic index diet for 10 days. 1º endpoint: insulin sensitivity as measured by the modified Frequently Sampled Intravenous Glucose Tolerance Test (FSIVGTT). 2º endpoints: CVD risk factors; postprandial studies of oxidative stress; thermic effect of food.
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Ages Eligible for Study:
18 Years to 35 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
age 18 to 35 years
BMI ≥ 27 ≤45 kg/m2
willingness to refrain from alcohol and caffeinated beverage consumption for duration of study
major medical illness
an abnormal screening laboratory test
taking any prescription medications that might affect body weight
current smoking (1 cigarette during any of the last 7 days)