Ambulatory Blood Pressure Monitoring for Antihypertensive Treatment Guidance

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00139984
Recruitment Status : Completed
First Posted : August 31, 2005
Last Update Posted : February 2, 2017
Information provided by (Responsible Party):
University Hospital, Basel, Switzerland

Brief Summary:
The purpose of this study is to determine whether in patients with arterial hypertension, treatment guidance using 24-hour blood pressure measurement results in better blood pressure control compared to treatment guidance using office blood pressure measurement.

Condition or disease Intervention/treatment Phase
Hypertension Device: 24 hour blood pressure measurement Phase 4

Detailed Description:

Blood pressure control in arterial hypertension remains poor, despite the availability of effective drug treatment. Therefore, strategies to increase blood pressure control are urgently needed. 24 hour blood pressure is a better predictor of cardiovascular morbidity and mortality than office blood pressure. Furthermore, the lower variability of measurements over time of 24 hour blood pressure could allow better adjustment of antihypertensive therapy. However, there are only scarce data about antihypertensive treatment adjustment using 24 hour blood pressure instead of office blood pressure.

Aim: To test the hypothesis that a 24 hour blood pressure guided therapy is is more effective in reaching blood pressure control when compared to conventional office blood pressure guided therapy.

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 170 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single
Primary Purpose: Treatment
Official Title: Impact of Ambulatory Blood Pressure Monitoring for Antihypertensive Treatment Guidance in Medical Outpatients: The Hyper-ABC Study
Study Start Date : October 2003
Actual Study Completion Date : May 2007

Resource links provided by the National Library of Medicine

Primary Outcome Measures :
  1. Change in 24-hour systolic blood pressure from baseline to 1 year

Secondary Outcome Measures :
  1. Change in 24-hour diastolic blood pressure from baseline to 1 year
  2. Primary outcome measure in patients with treated hypertension at baseline

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Uncontrolled hypertension (office BP >139/89mmHg AND 24h BP >129/79mmHg)

Exclusion Criteria:

  • Severe concomitant illness including heart failure, significant valvular heart disease or malignancy

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00139984

Medical Outpatient Clinic, University Hospital Basel
Basel, Switzerland, 4031
Private Practice
Basel, Switzerland, 4057
Sponsors and Collaborators
University Hospital, Basel, Switzerland
Principal Investigator: David Conen, MD Cardiology, University Hospital Basel

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: University Hospital, Basel, Switzerland Identifier: NCT00139984     History of Changes
Other Study ID Numbers: EKBB183/03
First Posted: August 31, 2005    Key Record Dates
Last Update Posted: February 2, 2017
Last Verified: February 2017

Keywords provided by University Hospital, Basel, Switzerland:
Ambulatory blood pressure monitoring
Blood pressure
Risk assessment

Additional relevant MeSH terms:
Vascular Diseases
Cardiovascular Diseases
Antihypertensive Agents