Study of the Distractibility Syndrome in Patients With Progressive Supranuclear Palsy
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ClinicalTrials.gov Identifier: NCT00139373
Recruitment Status : Unknown
Verified July 2005 by Groupe Hospitalier Pitie-Salpetriere. Recruitment status was: Recruiting
First Posted : August 31, 2005
Last Update Posted : September 14, 2007
Groupe Hospitalier Pitie-Salpetriere
Institut National de la Santé Et de la Recherche Médicale, France
The syndrome of distractibility is a behavioral disorder induced by a lesion or a dysfunction of the frontal lobe. This sign is frequent in patients with progressive supranuclear palsy (PSP), a neurodegenerative disorder with severe neuronal loss in the prefrontal cortex and cholinergic systems, in particular in the Meynert basalis nucleus. This could participate in the occurrence of the distractibility in these patients. The aim of this study is to evaluate the effect of the donepezil, an anticholinesterase, on the distractibility in PSP patients, by using oculomotor and neuropsychological assessments.
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